| Literature DB >> 1468838 |
Abstract
The age-specific efficacy of a vaccine depends upon the mechanism of vaccine action and the force of infection in the unvaccinated subpopulation. Consequently, inferences concerning the persistence of vaccine-induced immunity cannot in general be made directly from age-specific vaccine efficacy estimates. The definition, estimation and interpretation of age-specific vaccine efficacy measures are discussed using simple models of vaccine action. The methods are applied to data on measles and pertussis vaccines.Entities:
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Year: 1992 PMID: 1468838 DOI: 10.1093/ije/21.5.1014
Source DB: PubMed Journal: Int J Epidemiol ISSN: 0300-5771 Impact factor: 7.196