| Literature DB >> 14687946 |
Dubravko Forcić1, Marijana Baricević, Renata Zgorelec, Vjekoslava Kruzić, Bernard Kaić, Branka Marusić Della Marina, Ljerka Cvitanović Sojat, Goran Tesović, Renata Mazuran.
Abstract
Two cases of subacute sclerosing panencephalitis (SSPE), diagnosed in Croatia in 2002, were investigated. The coding regions of the matrix (M), hemagglutinin (H) and nucleoprotein (N) genes of measles virus were sequenced following direct RT-PCR amplification of viral RNA extracted from brain tissue. Phylogenetic analysis of the sequences of H and N genes, showed that both strains belonged to genotype D6. No vaccine strain was detected although both patients had been previously immunized. The comparison of analyzed sequences of two SSPE causative viruses with corresponding sequences of D6 genotype and with each other revealed a number of mutations in N and H gene sequences. In comparison to the Edmonston reference strain, the M gene of the SSPE viruses showed the characteristic biased hypermutation and a premature termination codon in one of the patients.Entities:
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Year: 2004 PMID： 14687946 DOI： 10.1016/j.virusres.2003.10.003
Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303