BACKGROUND: Ovarian cancer is the leading cause of death due to gynecological malignancies among women. The extent of free radical induced oxidative stress can be exacerbated by the decreased efficiency of antioxidant mechanisms. The present study was conducted to investigate the extent of oxidative stress and the levels of antioxidants in the circulation of ovarian cancer patients. METHODS: Plasma thiobarbituric acid reactive substances (TBARS) and conjugated dienes (CD) and the levels of antioxidants such as superoxide dismutase (SOD), catalase (CAT), vitamin C and vitamin E were estimated in the circulation of 30 ovarian cancer patients and an equal number of age-matched normal subjects as control. RESULTS: Significantly increased concentrations of plasma TBARS and CD and significantly lowered levels of SOD, CAT, vitamin C and vitamin E were observed in ovarian cancer patients as compared with normal subjects. CONCLUSION: The low levels of SOD, CAT, vitamin C and vitamin E in the plasma of ovarian cancer patients may be due to their increased utilization to scavenge lipid peroxides as well as their sequestration by tumor cells. Increased levels of lipid peroxidation may be due to excessive oxidative stress caused by incessant ovulation or epithelial inflammation.
BACKGROUND:Ovarian cancer is the leading cause of death due to gynecological malignancies among women. The extent of free radical induced oxidative stress can be exacerbated by the decreased efficiency of antioxidant mechanisms. The present study was conducted to investigate the extent of oxidative stress and the levels of antioxidants in the circulation of ovarian cancerpatients. METHODS: Plasma thiobarbituric acid reactive substances (TBARS) and conjugated dienes (CD) and the levels of antioxidants such as superoxide dismutase (SOD), catalase (CAT), vitamin C and vitamin E were estimated in the circulation of 30 ovarian cancerpatients and an equal number of age-matched normal subjects as control. RESULTS: Significantly increased concentrations of plasma TBARS and CD and significantly lowered levels of SOD, CAT, vitamin C and vitamin E were observed in ovarian cancerpatients as compared with normal subjects. CONCLUSION: The low levels of SOD, CAT, vitamin C and vitamin E in the plasma of ovarian cancerpatients may be due to their increased utilization to scavenge lipid peroxides as well as their sequestration by tumor cells. Increased levels of lipid peroxidation may be due to excessive oxidative stress caused by incessant ovulation or epithelial inflammation.
Authors: Jennifer Permuth-Wey; Y Ann Chen; Ya-Yu Tsai; Zhihua Chen; Xiaotao Qu; Johnathan M Lancaster; Heather Stockwell; Getachew Dagne; Edwin Iversen; Harvey Risch; Jill Barnholtz-Sloan; Julie M Cunningham; Robert A Vierkant; Brooke L Fridley; Rebecca Sutphen; John McLaughlin; Steven A Narod; Ellen L Goode; Joellen M Schildkraut; David Fenstermacher; Catherine M Phelan; Thomas A Sellers Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-03-29 Impact factor: 4.254
Authors: Shawn A Ritchie; Dushmanthi Jayasinghe; Gerald F Davies; Pearson Ahiahonu; Hong Ma; Dayan B Goodenowe Journal: J Exp Clin Cancer Res Date: 2011-05-17