In vivo demonstration of the ultrasound-modulated light technique.

We present, to our knowledge for the first time, results of ultrasound-modulated light signals on living tissues. In particular, we analyze, both theoretically and experimentally, the effect of speckle fluctuations on the signal. We find that two different kinds of noise compete--shot noise and speckle noise--and are present at different levels in static phantoms and ex vivo tissue samples on the one hand and in dynamic phantoms and living tissues on the other hand.