OBJECTIVE: To evaluate the prevalence of hemoglobin "S" (Hb "S") in babies born at the Instituto Materno Infantil de Pernambuco (IMIP) and its occurrence according to sex, birth weight and Apgar score. METHODS: We carried out a cross-sectional descriptive study of all babies born in the IMIP from October 1996 to March 1997. We used alkaline electrophoresis to analyze cord blood samples (1,988). Data for other variables were collected from medical reports. EPI-Info 6.0 was used to analyze the data. RESULTS: We found 105 (5.3%) newborns with Hb "S": 102 (5.1%.) as sickle cell trait (Hb "FAS"), and 3 (0.2%) as sickle cell disease (Hb "SC"). No cases of homozygosis were found. Newborns with and without Hb "S" did not differ in relation to sex, birth weight and Apgar score. CONCLUSIONS: We suggest the implementation of neonatal screening for hemoglobinopathies for all the newborns in Recife, Brazil, with further follow up focusing on genetic counseling for suspected and positive cases.
OBJECTIVE: To evaluate the prevalence of hemoglobin "S" (Hb "S") in babies born at the Instituto Materno Infantil de Pernambuco (IMIP) and its occurrence according to sex, birth weight and Apgar score. METHODS: We carried out a cross-sectional descriptive study of all babies born in the IMIP from October 1996 to March 1997. We used alkaline electrophoresis to analyze cord blood samples (1,988). Data for other variables were collected from medical reports. EPI-Info 6.0 was used to analyze the data. RESULTS: We found 105 (5.3%) newborns with Hb "S": 102 (5.1%.) as sickle cell trait (Hb "FAS"), and 3 (0.2%) as sickle cell disease (Hb "SC"). No cases of homozygosis were found. Newborns with and without Hb "S" did not differ in relation to sex, birth weight and Apgar score. CONCLUSIONS: We suggest the implementation of neonatal screening for hemoglobinopathies for all the newborns in Recife, Brazil, with further follow up focusing on genetic counseling for suspected and positive cases.
Authors: Julio Da Luz; Amalia Avila; Sandra Icasuriaga; María Gongóra; Luis Castillo; Alejandra Serrón; Elza Miyuki Kimura; Fernando Ferreira Costa; Mónica Sans; Maria de Fátima Sonati Journal: Genet Mol Biol Date: 2013-07-19 Impact factor: 1.771