Literature DB >> 14685315

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.

Alan G Sutherland1, Juan Alvarez, Weidong Ding, K W Foreman, Cynthia Hess Kenny, Pornpen Labthavikul, Lidia Mosyak, Peter J Petersen, Thomas S Rush, Alexey Ruzin, Desiree H H Tsao, Karen L Wheless.   

Abstract

Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhibitory activity.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14685315     DOI： 10.1039/b312016c

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  9 in total

Review 1.  Essential biological processes of an emerging pathogen: DNA replication, transcription, and cell division in Acinetobacter spp.

Authors:  Andrew Robinson; Anthony J Brzoska; Kylie M Turner; Ryan Withers; Elizabeth J Harry; Peter J Lewis; Nicholas E Dixon
Journal:  Microbiol Mol Biol Rev       Date:  2010-06       Impact factor: 11.056

2.  Modulating protein-protein interactions with small molecules: the importance of binding hotspots.

Authors:  Ratna Rajesh Thangudu; Stephen H Bryant; Anna R Panchenko; Thomas Madej
Journal:  J Mol Biol       Date:  2011-12-16       Impact factor: 5.469

Review 3.  Discovery of anti-TB agents that target the cell-division protein FtsZ.

Authors:  Kunal Kumar; Divya Awasthi; William T Berger; Peter J Tonge; Richard A Slayden; Iwao Ojima
Journal:  Future Med Chem       Date:  2010-08       Impact factor: 3.808

Review 4.  Development of Protein-Protein Interaction Inhibitors for the Treatment of Infectious Diseases.

Authors:  Andrew F Voter; James L Keck
Journal:  Adv Protein Chem Struct Biol       Date:  2017-08-24       Impact factor: 3.507

5.  An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.

Authors:  Neil R Stokes; Nicola Baker; James M Bennett; Joanne Berry; Ian Collins; Lloyd G Czaplewski; Alastair Logan; Rebecca Macdonald; Leanne Macleod; Hilary Peasley; Jeffrey P Mitchell; Narendra Nayal; Anju Yadav; Anil Srivastava; David J Haydon
Journal:  Antimicrob Agents Chemother       Date:  2012-10-31       Impact factor: 5.191

6.  ZipA binds to FtsZ with high affinity and enhances the stability of FtsZ protofilaments.

Authors:  Anuradha Kuchibhatla; Anusri Bhattacharya; Dulal Panda
Journal:  PLoS One       Date:  2011-12-02       Impact factor: 3.240

Review 7.  Determinants of Bacterial Morphology: From Fundamentals to Possibilities for Antimicrobial Targeting.

Authors:  Muriel C F van Teeseling; Miguel A de Pedro; Felipe Cava
Journal:  Front Microbiol       Date:  2017-07-10       Impact factor: 5.640

Review 8.  Protein-protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics.

Authors:  Laura Carro
Journal:  Beilstein J Org Chem       Date:  2018-11-21       Impact factor: 2.883

Review 9.  A key bacterial cytoskeletal cell division protein FtsZ as a novel therapeutic antibacterial drug target.

Authors:  Mujeeb Ur Rahman; Ping Wang; Na Wang; Yaodong Chen
Journal:  Bosn J Basic Med Sci       Date:  2020-08-03       Impact factor: 3.363
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.