| Literature DB >> 14684343 |
Haiyin He1, Bo Shen, Peter J Petersen, William J Weiss, Hui Y Yang, Ting-Zhong Wang, Russell G Dushin, Frank E Koehn, Guy T Carter.
Abstract
A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin alpha (1) with potent activity against G+ bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.Entities:
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Year: 2004 PMID： 14684343 DOI： 10.1016/j.bmcl.2003.09.071
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823