| Literature DB >> 14684342 |
John G Catalano1, David N Deaton, Eric S Furfine, Annie M Hassell, Robert B McFadyen, Aaron B Miller, Larry R Miller, Lisa M Shewchuk, Derril H Willard, Lois L Wright.
Abstract
The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.Entities:
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Year: 2004 PMID： 14684342 DOI： 10.1016/j.bmcl.2003.09.088
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823