Literature DB >> 14684329

Highly potent PDE4 inhibitors with therapeutic potential.

Hiroshi Ochiai1, Tazumi Ohtani, Akiharu Ishida, Kensuke Kusumi, Masashi Kato, Hiroshi Kohno, Katuya Kishikawa, Takaaki Obata, Hisao Nakai, Masaaki Toda.   

Abstract

Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

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Year:  2004        PMID： 14684329     DOI： 10.1016/j.bmcl.2003.09.087

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors.

Authors:  Shilong Zheng; Gurpreet Kaur; Huanchen Wang; Minyong Li; Megan Macnaughtan; Xiaochuan Yang; Suazette Reid; James Prestegard; Binghe Wang; Hengming Ke
Journal:  J Med Chem       Date:  2008-12-25       Impact factor: 7.446

2.  Pharmacophore modeling and virtual screening for the discovery of new type 4 cAMP phosphodiesterase (PDE4) inhibitors.

Authors:  Miaomiao Niu; Fenggong Dong; Shi Tang; Guissi Fida; Jingyi Qin; Jiadan Qiu; Kangbo Liu; Weidong Gao; Yueqing Gu
Journal:  PLoS One       Date:  2013-12-10       Impact factor: 3.240
  2 in total

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