| Literature DB >> 14684321 |
Brian M Mathes1, Kevin J Hudziak, John M Schaus, Yao-Chang Xu, David L Nelson, David B Wainscott, Suzanne E Nutter, Wendy H Gough, Theresa A Branchek, John M Zgombick, Sandra A Filla.
Abstract
Synthesis and evaluation of a series of 2,3,5- and 3,5-substituted furo[3,2-b]pyridines were undertaken in order to investigate their utility as bioisosteres of 5-HT(1F) receptor agonist indole analogues, 1-3. The replacement proved to be effective, providing compounds with similar 5-HT(1F) receptor affinity and improved selectivity when compared with the indole analogues. Through these studies we identified 4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-yl]-benzamide (5), a potent and selective 5-HT(1F) receptor agonist with the potential to treat acute migraine.Entities:
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Year: 2004 PMID： 14684321 DOI： 10.1016/j.bmcl.2003.09.091
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823