| Literature DB >> 14684317 |
Grigory Veinberg1, Irina Shestakova, Maxim Vorona, Iveta Kanepe, Edmunds Lukevics.
Abstract
6-alkylidenepenicillanate sulfoxides and sulfones were synthesized on the base of 6-oxopenicillanate esters. The targeted splitting of their thiazolidine ring led to the formation of 3-alkylidene substituted 4-heteryldithio and 4-methylsulfonyl azetidin-2-ones. Some of mono and bicyclic beta-lactams revealed potent cytotoxic properties towards monolayer tumor cells in <10-microM concentrations.Entities:
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Year: 2004 PMID： 14684317 DOI： 10.1016/j.bmcl.2003.09.078
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823