| Literature DB >> 14684309 |
Yue-Mei Zhang1, Stuart Cockerill, Stephen B Guntrip, David Rusnak, Kathryn Smith, Dana Vanderwall, Edgar Wood, Karen Lackey.
Abstract
A series of 6-alkoxy-4-anilinoquinazoline compounds was prepared and evaluated for in vitro inhibition of the erbB2 and EGFR kinase activity. The IC(50) values of the best compounds were below 0.10 uM. Further, several of these compounds inhibit the growth of erbB2 and EGFR over-expressing tumor cell lines at concentrations below 1 uM.Entities:
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Year: 2004 PMID： 14684309 DOI： 10.1016/j.bmcl.2003.10.010
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823