| Literature DB >> 14684306 |
Jin Li1, Kristin M Lundy DeMello, Henry Cheng, Subas M Sakya, Brian S Bronk, Robert J Rafka, Burton H Jaynes, Carl B Ziegler, Carolyn Kilroy, Donald W Mann, Eric L Nimz, Michael P Lynch, Michelle L Haven, Nicole L Kolosko, Martha L Minich, Chao Li, Jason K Dutra, Bryson Rast, Rhonda M Crosson, Barry J Morton, Glen W Kirk, Kathleen M Callaghan, David A Koss, Andrei Shavnya, Lisa A Lund, Scott B Seibel, Carol F Petras, Annette Silvia.
Abstract
Structure-activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes are described. This led to the identification of 12a as a lead candidate for further progression. The in vitro and in vivo activity of 12a for the canine COX-2 enzyme as well as its in vivo efficacy and pharmacokinetic properties in dog are highlighted.Entities:
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Year: 2004 PMID： 14684306 DOI： 10.1016/j.bmcl.2003.10.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823