Literature DB >> 14684298

Peptide deformylase inhibitors with activity against respiratory tract pathogens.

Stephen P East1, R Paul Beckett, Daniel C Brookings, John M Clements, Sheila Doel, Kenneth Keavey, Gilles Pain, Helen K Smith, Wayne Thomas, Alison J Thompson, Richard S Todd, Mark Whittaker.   

Abstract

A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3' amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections.

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Year:  2004        PMID： 14684298     DOI： 10.1016/j.bmcl.2003.10.013

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Pharmacokinetics in animals and humans of a first-in-class peptide deformylase inhibitor.

Authors:  Sandhya Ramanathan-Girish; Juliet McColm; John M Clements; Phil Taupin; Sue Barrowcliffe; John Hevizi; Sharon Safrin; Clive Moore; Gary Patou; Heinz Moser; Alison Gadd; Ute Hoch; Vernon Jiang; Denene Lofland; Kirk W Johnson
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

2.  Insights from ligand and structure based methods in virtual screening of selective Ni-peptide deformylase inhibitors.

Authors:  Ravi Shekar Ananthula; Muttineni Ravikumar; S K Mahmood; M N S Pavan Kumar
Journal:  J Mol Model       Date:  2011-05-12       Impact factor: 1.810

3.  Comparative QSAR studies on peptide deformylase inhibitors.

Authors:  Ji Young Lee; Munikumar Reddy Doddareddy; Yong Seo Cho; Hyunah Choo; Hun Yeong Koh; Jae-Hoon Kang; Kyoung Tai No; Ae Nim Pae
Journal:  J Mol Model       Date:  2007-02-27       Impact factor: 2.172
  3 in total

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