| Literature DB >> 14684295 |
Dawei Ma1, Wengen Wu, Guoxin Yang, Jingya Li, Jia Li, Qizhuang Ye.
Abstract
The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups.Entities:
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Year: 2004 PMID： 14684295 DOI： 10.1016/j.bmcl.2003.10.026
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823