| Literature DB >> 14684289 |
Michael J Munchhof1, Jean S Beebe, Jeffery M Casavant, Beth A Cooper, Jonathan L Doty, R Carla Higdon, Stephen M Hillerman, Catherine I Soderstrom, Elisabeth A Knauth, Matthew A Marx, Ann Marie K Rossi, Susan B Sobolov, Jianmin Sun.
Abstract
Novel classes of thienopyrimidines and thienopyridines have been identified as potent inhibitors of VEGFR-2 kinase. The synthesis and SAR of these compounds is presented, along with successful efforts to diminish EGFR activity present in the lead series.Entities:
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Year: 2004 PMID： 14684289 DOI： 10.1016/j.bmcl.2003.10.030
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823