Literature DB >> 14683457

DGAT: novel therapeutic target for obesity and type 2 diabetes mellitus.

Angela Subauste1, Charles F Burant.   

Abstract

Obesity is currently an exceptionally common problem in humans. The last several years have produced a significant number of breakthroughs in obesity related areas of investigation. Triglycerides are considered the main form of storage of excess calories in fat. A key enzyme in the synthesis of triglycerides is acylCoA: diacylglycerol acyltransferase (DGAT). Recent studies have shown that mice deficient in this enzyme are resistant to diet induced obesity and have increased insulin and leptin sensitivity. These effects suggest that inhibition of DGAT in vivo may be a novel therapeutic target not only for obesity but also for diabetes.

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Year:  2003        PMID： 14683457     DOI： 10.2174/1568008033340081

Source DB:  PubMed          Journal:  Curr Drug Targets Immune Endocr Metabol Disord        ISSN： 1568-0088


  6 in total

1.  Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis.

Authors:  Jingsong Cao; Jian-Liang Li; Dongmei Li; James F Tobin; Ruth E Gimeno
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-14       Impact factor: 11.205

2.  Sustained rise in triacylglycerol synthesis and increased epididymal fat mass when rats cease voluntary wheel running.

Authors:  David S Kump; Frank W Booth
Journal:  J Physiol       Date:  2005-03-17       Impact factor: 5.182

3.  The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain ADP1: characterization of a novel type of acyltransferase.

Authors:  Tim Stöveken; Rainer Kalscheuer; Ursula Malkus; Rudolf Reichelt; Alexander Steinbüchel
Journal:  J Bacteriol       Date:  2005-02       Impact factor: 3.490

4.  Deconstructing the DGAT1 enzyme: membrane interactions at substrate binding sites.

Authors:  Jose L S Lopes; Leila M Beltramini; Bonnie A Wallace; Ana P U Araujo
Journal:  PLoS One       Date:  2015-02-26       Impact factor: 3.240

5.  Aqueous Extract from Pepino (Solanum muricatum Ait.) Attenuated Hyperlipidemia and Cardiac Oxidative Stress in Diabetic Mice.

Authors:  Zhi-Hong Wang; Cheng-Chin Hsu; Mei-Chin Yin
Journal:  ISRN Obes       Date:  2012-07-08

6.  Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors.

Authors:  Dong Jin Hong; Seung Hyun Jung; Jisook Kim; Danbee Jung; Young Gil Ahn; Kwee Hyun Suh; Kyung Hoon Min
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  6 in total

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