J N Kostraba1, E C Gay, M Rewers, R F Hamman. 1. Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262.
Abstract
OBJECTIVE: To investigate whether higher IDDM incidence rates occurred in areas with high nitrate levels in their potable water supplies. RESEARCH DESIGN AND METHODS: Incidence rates for the 63 counties in Colorado were calculated using the Colorado IDDM Registry of children diagnosed < 18 yr of age between 1978 and 1988 (n = 1280). A weighted average of the nitrate levels from each water district within each county was calculated using data collected by the Colorado Department of Health between 1984 and 1988. RESULTS: The rs between nitrate levels and IDDM incidence was 0.26 (P = 0.03). After controlling for differences in ethnicity, counties with water nitrate levels in the third tertile (0.77-8.2 mg/L) had a significantly increased risk of IDDM compared with those in the first tertile (0.0-0.084 mg/L) (rp = 0.29, P = 0.02). CONCLUSIONS: This ecological analysis suggests that low-level nitrate exposure through drinking water may play a role in the etiology of IDDM, perhaps as a promoter through the generation of free radicals.
OBJECTIVE: To investigate whether higher IDDM incidence rates occurred in areas with high nitrate levels in their potable water supplies. RESEARCH DESIGN AND METHODS: Incidence rates for the 63 counties in Colorado were calculated using the Colorado IDDM Registry of children diagnosed < 18 yr of age between 1978 and 1988 (n = 1280). A weighted average of the nitrate levels from each water district within each county was calculated using data collected by the Colorado Department of Health between 1984 and 1988. RESULTS: The rs between nitrate levels and IDDM incidence was 0.26 (P = 0.03). After controlling for differences in ethnicity, counties with water nitrate levels in the third tertile (0.77-8.2 mg/L) had a significantly increased risk of IDDM compared with those in the first tertile (0.0-0.084 mg/L) (rp = 0.29, P = 0.02). CONCLUSIONS: This ecological analysis suggests that low-level nitrate exposure through drinking water may play a role in the etiology of IDDM, perhaps as a promoter through the generation of free radicals.
Authors: Mohammad Zendehbad; Majid Mostaghelchi; Mohsen Mojganfar; Peter Cepuder; Willibald Loiskandl Journal: Environ Sci Pollut Res Int Date: 2022-06-13 Impact factor: 5.190