| Literature DB >> 14682754 |
Torsten Haack1, Serdar Kurtkaya, James P Snyder, Gunda I Georg.
Abstract
The synthesis of compound 1, a precursor for the synthesis of the oximidine II core structure 2, is described. An undesired C8-C9 isomerization occurred during the intramolecular Castro-Stephens reaction leading to macrocyle 3. The thermodynamic driving force for this unexpected isomerization was established by DFT and MP2 calculations. [reaction: see text]Entities:
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Year: 2003 PMID： 14682754 DOI： 10.1021/ol036007d
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005