| Literature DB >> 14682716 |
Young-Ah Kim1, Hae-Mi Chung, Jin-Seon Park, Wonja Choi, Juyoung Min, Nok-Hyun Park, Ki-Hwan Kim, Gil-Ja Jhon, So-Yeop Han.
Abstract
Four novel lysophosphatidylcholine (lysoPC) analogues, (S)-N-stearoyl-O-phosphocholineserine methyl ester [(S)-1a], (R)-1-lyso-2-stearoylamino-2-deoxy-sn-glycero-3-phosphatidylcholine [(R)-2a], (R)-N-stearoyl-O-phosphocholineserine methyl ester [(R)-1b], and (S)-1-lyso-2-stearoylamino-2-deoxy-sn-glycero-3-phosphatidylcholine [(S)-2b], were synthesized starting from serine as a chiral template. These synthetic compounds exhibited greatly enhanced hyphal transition inhibitory activity in Candida as compared to the natural lysoPC.Entities:
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Year: 2003 PMID： 14682716 DOI： 10.1021/jo034969s
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354