| Literature DB >> 14682706 |
B Narasimhulu Naidu1, Margaret E Sorenson, Timothy P Connolly, Yasutsugu Ueda.
Abstract
In water, the rate of Michael addition of amines and thiols to dehydroalanine amides was greatly accelerated, leading to shorter reaction times and higher yields. The scope of the new conditions was tested with a range of amines, thiols, and dehydroalanine amides. The ease and efficiency of this method provides an attractive route to the synthesis of natural and unnatural amino acid derivatives.Entities:
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Year: 2003 PMID： 14682706 DOI： 10.1021/jo034762z
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354