OBJECTIVE: To investigate whether smoking, alcohol intake, female hormonal or anthropometric factors affect melanoma risk. METHODS: Using Cox proportional hazards regression analyses, we analyzed 68,588 white subjects (79% female) from the US Radiologic Technologists (USRT) Study who were cancer-free (other than non-melanoma skin cancer) as of the first of two self-administered questionnaires. Follow-up covered 698, 028 person-years, with 207 cases of melanoma. RESULTS: We found that melanoma risk was not associated with height, weight or BMI, nor with age at menarche, menopausal status, use of hormone replacement therapy, parity, age at first birth or oral contraceptive use. Melanoma risk was elevated with increasing alcohol use (RR: 2.1: 95% CI: 0.9-4.8, for > 14 drinks/week compared to never drinking; (p(trend) = 0.08)). Smoking for long durations compared to never smoking was inversely related to melanoma risk (RR: 0.6; 0.3-1.3; > or = 30 years; p(trend) = 0.03), though risk was not associated with number of packs smoked per day. CONCLUSIONS: None of the anthropometric or female reproductive/hormonal factors evaluated were related to melanoma risk. It is unclear whether the positive association with alcohol intake and inverse association with smoking for long duration are causal. The alcohol and smoking findings warrant detailed assessment in studies with substantial statistical power where potential biases can be more fully evaluated.
OBJECTIVE: To investigate whether smoking, alcohol intake, female hormonal or anthropometric factors affect melanoma risk. METHODS: Using Cox proportional hazards regression analyses, we analyzed 68,588 white subjects (79% female) from the US Radiologic Technologists (USRT) Study who were cancer-free (other than non-melanoma skin cancer) as of the first of two self-administered questionnaires. Follow-up covered 698, 028 person-years, with 207 cases of melanoma. RESULTS: We found that melanoma risk was not associated with height, weight or BMI, nor with age at menarche, menopausal status, use of hormone replacement therapy, parity, age at first birth or oral contraceptive use. Melanoma risk was elevated with increasing alcohol use (RR: 2.1: 95% CI: 0.9-4.8, for > 14 drinks/week compared to never drinking; (p(trend) = 0.08)). Smoking for long durations compared to never smoking was inversely related to melanoma risk (RR: 0.6; 0.3-1.3; > or = 30 years; p(trend) = 0.03), though risk was not associated with number of packs smoked per day. CONCLUSIONS: None of the anthropometric or female reproductive/hormonal factors evaluated were related to melanoma risk. It is unclear whether the positive association with alcohol intake and inverse association with smoking for long duration are causal. The alcohol and smoking findings warrant detailed assessment in studies with substantial statistical power where potential biases can be more fully evaluated.
Authors: Maria C Kessides; Lee Wheless; Judith Hoffman-Bolton; Sandra Clipp; Rhoda M Alani; Anthony J Alberg Journal: J Am Acad Dermatol Date: 2010-03-23 Impact factor: 11.527
Authors: Jessica T Kubo; Michael T Henderson; Manisha Desai; Jean Wactawski-Wende; Marcia L Stefanick; Jean Y Tang Journal: Cancer Causes Control Date: 2013-10-31 Impact factor: 2.506
Authors: Meg R Gerstenblith; Preetha Rajaraman; Elizabeth Khaykin; Michele M Doody; Bruce H Alexander; Martha S Linet; D Michal Freedman Journal: Int J Cancer Date: 2012-01-31 Impact factor: 7.396
Authors: Julia A Newton-Bishop; Samantha Beswick; Juliette Randerson-Moor; Yu-Mei Chang; Paul Affleck; Faye Elliott; May Chan; Susan Leake; Birute Karpavicius; Sue Haynes; Kairen Kukalizch; Linda Whitaker; Sharon Jackson; Edwina Gerry; Clarissa Nolan; Chandra Bertram; Jerry Marsden; David E Elder; Jennifer H Barrett; D Timothy Bishop Journal: J Clin Oncol Date: 2009-09-21 Impact factor: 44.544