Literature DB >> 146823

The role of glutathione in renal cortical tissue. Effects of diamide on Na+ and GSSG levels, amino acid transport and Na+-K+-ATPase activity.

D J Pillon, L Moree, H Rocha, D H Pashley, J Mendicino, F H Leibach.   

Abstract

The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na+-dependent and Na+-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 146823     DOI： 10.1007/bf00280276

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  35 in total

1.  Effects of 6,6'-dithiodinicotinic acid, a thiol reagent on several mitochondrial functions: coupling mechanism, ATPase and anion transport.

Authors:  S Abou-Khalil; N Sabadie-Pialoux; D Gautheron
Journal:  Biochem Pharmacol       Date:  1975-01-01       Impact factor: 5.858

2.  Phosphorylation and dephosphorylation of renal brush border membranes by protein kinase and phosphoprotein phosphatase.

Authors:  H Abou-Issa; J Mendicino; F Leibach; D Pillion
Journal:  FEBS Lett       Date:  1975-02-01       Impact factor: 4.124

3.  Reversible inhibition by diamide of cyclic AMP-dependent protein kinases from bovine thyroid.

Authors:  M McClung; J Miller
Journal:  Biochem Biophys Res Commun       Date:  1977-06-06       Impact factor: 3.575

4.  Reconstitution of specific Na-dependent D-glucose transport in liposomes by Triton X-100 extracted proteins from purified brush border membranes of hamster small intestine.

Authors:  R K Crane; P Malathi; H Preiser
Journal:  Biochem Biophys Res Commun       Date:  1976-08-23       Impact factor: 3.575

5.  Inhibitory effects of mycotoxins on Na+-dependent transport of glycine in rabbit reticulocytes.

Authors:  Y Ueno; H Matsumoto; K Ishi; K I Kukita
Journal:  Biochem Pharmacol       Date:  1976-09-15       Impact factor: 5.858

6.  Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathione.

Authors:  A Holmgren
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

7.  Cyclic adenosine monophosphate-stimulated transport of amino acids in kidney cortex.

Authors:  I W Weiss; K Morgan; J M Phang
Journal:  J Biol Chem       Date:  1972-02-10       Impact factor: 5.157

8.  Diamide, a new reagent for the intracellular oxidation of glutathione to the disulfide.

Authors:  N S Kosower; E M Kosower; B Wertheim; W S Correa
Journal:  Biochem Biophys Res Commun       Date:  1969-11-06       Impact factor: 3.575

9.  The inhibition of ribonucleic acid synthesis by the thiol-oxidizing agent, diamide, in Escherichia coli.

Authors:  T Zehavi-Willner; R Wax; E M. Kosower
Journal:  FEBS Lett       Date:  1970-07-29       Impact factor: 4.124

10.  Heterogeneity of the beta-amino-preferring transport system in rat kidney cortex. Differential influence of glutathione oxidation.

Authors:  R W Chesney; D K Jax
Journal:  Biochim Biophys Acta       Date:  1977-04-01
View more
  1 in total

1.  The mechanism of bromobenzene-induced cytotoxicity studied with isolated hepatocytes.

Authors:  H Thor; S Orrenius
Journal:  Arch Toxicol       Date:  1980-03       Impact factor: 5.153
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.