Literature DB >> 14682051

Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome.

Dong P Liu1, Cecilia Schmidt, Timothy Billings, Muriel T Davisson.   

Abstract

The Ts65Dn mouse is a segmentally trisomic model for Down syndrome. Until now, Ts65Dn mice have been identified by the laborious methods of either chromosomal analysis of cultured peripheral lymphocytes or fluorescent in situ hybridization (FISH). We report here a quantitative PCR method for genotyping Ts65Dn mice, as well as a phenotypic description for visually preclassifying mice to be genotyped.

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Year:  2003        PMID： 14682051     DOI： 10.2144/03356st02

Source DB:  PubMed          Journal:  Biotechniques        ISSN： 0736-6205            Impact factor:   1.993


  36 in total

1.  Altered distribution of hippocampal interneurons in the murine Down Syndrome model Ts65Dn.

Authors:  Samuel Hernández-González; Raúl Ballestín; Rosa López-Hidalgo; Javier Gilabert-Juan; José Miguel Blasco-Ibáñez; Carlos Crespo; Juan Nácher; Emilio Varea
Journal:  Neurochem Res       Date:  2014-11-16       Impact factor: 3.996

2.  Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.

Authors:  Laura G Reinholdt; Yueming Ding; Griffith J Gilbert; Griffith T Gilbert; Anne Czechanski; Jeffrey P Solzak; Randall J Roper; Mark T Johnson; Leah Rae Donahue; Cathleen Lutz; Muriel T Davisson
Journal:  Mamm Genome       Date:  2011-09-28       Impact factor: 2.957

3.  Developmentally altered inhibition in Ts65Dn, a mouse model of Down syndrome.

Authors:  Ananya Mitra; Martina Blank; Daniel V Madison
Journal:  Brain Res       Date:  2012-01-03       Impact factor: 3.252

4.  The Down syndrome critical region regulates retinogeniculate refinement.

Authors:  Martina Blank; Peter G Fuerst; Beth Stevens; Navid Nouri; Lowry Kirkby; Deepti Warrier; Ben A Barres; Marla B Feller; Andrew D Huberman; Robert W Burgess; Craig C Garner
Journal:  J Neurosci       Date:  2011-04-13       Impact factor: 6.167

5.  Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice.

Authors:  Christy M Kelley; Brian E Powers; Ramon Velazquez; Jessica A Ash; Stephen D Ginsberg; Barbara J Strupp; Elliott J Mufson
Journal:  J Comp Neurol       Date:  2014-04-15       Impact factor: 3.215

6.  Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome.

Authors:  Sergey V Voronov; Samuel G Frere; Silvia Giovedi; Elizabeth A Pollina; Christelle Borel; Hong Zhang; Cecilia Schmidt; Ellen C Akeson; Markus R Wenk; Laurent Cimasoni; Ottavio Arancio; Muriel T Davisson; Stylianos E Antonarakis; Katheleen Gardiner; Pietro De Camilli; Gilbert Di Paolo
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-30       Impact factor: 11.205

7.  Two high throughput technologies to detect segmental aneuploidies identify new Williams-Beuren syndrome patients with atypical deletions.

Authors:  C Howald; G Merla; M C Digilio; S Amenta; R Lyle; S Deutsch; U Choudhury; A Bottani; S E Antonarakis; H Fryssira; B Dallapiccola; A Reymond
Journal:  J Med Genet       Date:  2005-07-01       Impact factor: 6.318

8.  Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model.

Authors:  Clara S Moore
Journal:  Mamm Genome       Date:  2006-10-03       Impact factor: 2.957

9.  CORP: Using transgenic mice to study skeletal muscle physiology.

Authors:  C Brooks Mobley; Ivan J Vechetti; Taylor R Valentino; John J McCarthy
Journal:  J Appl Physiol (1985)       Date:  2020-02-27

10.  Otitis media in a mouse model for Down syndrome.

Authors:  Fengchan Han; Heping Yu; Jiangping Zhang; Cong Tian; Cecilia Schmidt; Casey Nava; Muriel T Davisson; Qing Y Zheng
Journal:  Int J Exp Pathol       Date:  2009-10       Impact factor: 1.925
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