| Literature DB >> 14681909 |
Amanda J Myers1, Helen Marshall, Peter Holmans, Danielle Compton, Richard J P Crook, Adrian P Mander, Petra Nowotny, Scott Smemo, Melanie Dunstan, Luke Jehu, Jen C Wang, Marian Hamshere, John C Morris, Joanne Norton, Sumi Chakraventy, Nigel Tunstall, Simon Lovestone, Ronald Petersen, Michael O'Donovan, Lesley Jones, Julie Williams, Michael J Owen, John Hardy, Alison Goate.
Abstract
Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Abeta42 levels suggesting that a single locus may influence risk for AD by elevating plasma Abeta42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data. Copyright 2004 Wiley-Liss, Inc.Entities:
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Year: 2004 PMID： 14681909 DOI： 10.1002/ajmg.b.20036
Source DB: PubMed Journal: Am J Med Genet B Neuropsychiatr Genet ISSN： 1552-4841 Impact factor: 3.568