OBJECTIVE: Previously we failed to demonstrate a correlation between plaque type and symptoms in 165 carotid endarterectomy specimens. The purpose of this study was to analyze the relation between the anatomy of the carotid plaques and the presence of symptoms in 281 carotid endarterectomy specimens. METHODS: The patients were 213 men (mean age, 68 years) and 68 women (mean age, 68.7 years), with symptomatic disease (n = 133) or asymptomatic disease (n = 148). Specimens were processed for histologic analysis and immunohistochemistry. RESULTS: Plaques were categorized as complicated or noncomplicated, and ruptured or nonruptured. Risk factors could not be correlated with any pathologic or immunohistochemical findings or between plaque type and clinical symptoms. CONCLUSIONS: Almost 70% of plaque specimens demonstrated thrombus, intraplaque hemorrhage, or both. Thrombosis was observed in one fourth of specimens, and intraplaque hemorrhage in almost two thirds of specimens. Sixty four percent of plaques demonstrated neovascularization. It was not possible to demonstrate that complicated plaques (plaque rupture, thrombosis, intraplaque hemorrhage) are associated with symptoms, and it appears that such plaques may occur at any time, irrespective of symptoms.
OBJECTIVE: Previously we failed to demonstrate a correlation between plaque type and symptoms in 165 carotid endarterectomy specimens. The purpose of this study was to analyze the relation between the anatomy of the carotid plaques and the presence of symptoms in 281 carotid endarterectomy specimens. METHODS: The patients were 213 men (mean age, 68 years) and 68 women (mean age, 68.7 years), with symptomatic disease (n = 133) or asymptomatic disease (n = 148). Specimens were processed for histologic analysis and immunohistochemistry. RESULTS: Plaques were categorized as complicated or noncomplicated, and ruptured or nonruptured. Risk factors could not be correlated with any pathologic or immunohistochemical findings or between plaque type and clinical symptoms. CONCLUSIONS: Almost 70% of plaque specimens demonstrated thrombus, intraplaque hemorrhage, or both. Thrombosis was observed in one fourth of specimens, and intraplaque hemorrhage in almost two thirds of specimens. Sixty four percent of plaques demonstrated neovascularization. It was not possible to demonstrate that complicated plaques (plaque rupture, thrombosis, intraplaque hemorrhage) are associated with symptoms, and it appears that such plaques may occur at any time, irrespective of symptoms.
Authors: José Milei; Anna M Lavezzi; Barbara Bruni; Daniel R Grana; Francisco Azzato; Luigi Matturri Journal: Can J Cardiol Date: 2009-01 Impact factor: 5.223
Authors: Craig C Weinkauf; Kirsten Concha-Moore; Jonathan R Lindner; Edmund R Marinelli; Kyle P Hadinger; Sandipan Bhattacharjee; Scott S Berman; Kay Goshima; Luis R Leon; Terry O Matsunaga; Evan Unger Journal: J Vasc Surg Date: 2018-02-13 Impact factor: 4.268
Authors: Li Dong; William S Kerwin; Marina S Ferguson; Rui Li; Jinnan Wang; Huijun Chen; Gador Canton; Thomas S Hatsukami; Chun Yuan Journal: J Cardiovasc Magn Reson Date: 2009-12-15 Impact factor: 5.364
Authors: Yuan Huang; Zhongzhao Teng; Umar Sadat; Martin J Graves; Martin R Bennett; Jonathan H Gillard Journal: J Biomech Date: 2014-01-21 Impact factor: 2.712