Literature DB >> 14681457

MitoP2, an integrated database on mitochondrial proteins in yeast and man.

C Andreoli1, H Prokisch, K Hörtnagel, J C Mueller, M Münsterkötter, C Scharfe, T Meitinger.   

Abstract

The aim of the MitoP2 database (http://ihg.gsf.de/mitop2) is to provide a comprehensive list of mitochondrial proteins of yeast and man. Based on the current literature we created an annotated reference set of yeast and human proteins. In addition, data sets relevant to the study of the mitochondrial proteome are integrated and accessible via search tools and links. They include computational predictions of signalling sequences, and summarize results from proteome mapping, mutant screening, expression profiling, protein-protein interaction and cellular sublocalization studies. For each individual approach, specificity and sensitivity for allocating mitochondrial proteins was calculated. By providing the evidence for mitochondrial candidate proteins the MitoP2 database lends itself to the genetic characterization of human mitochondriopathies.

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Year:  2004        PMID： 14681457      PMCID： PMC308871          DOI： 10.1093/nar/gkh137

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


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