| Literature DB >> 14680843 |
Abbas Shakoori1, Gourou Fujii, Shin-Ichiro Yoshimura, Masashi Kitamura, Kazuhisa Nakayama, Takashi Ito, Hiroshi Ohno, Nobuhiro Nakamura.
Abstract
A family of five-pass transmembrane proteins (FinGERs) were identified from the protein sequence database. The family includes yeast Yip1p, Yip4p, Yip5p, and Yif1p, and also their plant, insects, nematode, and mammalian homologues, suggesting their conserved function in a broad range of species. Eight family members were found in human. Multiple sequence alignment revealed three regions conserved among all family members. All of the human family members were expressed widely in various tissues. The human proteins were localized in and around the Golgi apparatus and may also be in the ER to some extent. The Golgi apparatus was fragmented by overexpression of the five of the family members. Some of the members were found to interact by yeast two-hybrid analysis, suggesting the formation of a complex. These results suggest that FinGERs function in maintenance of the Golgi structure and/or transport between the ER and the Golgi apparatus.Entities:
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Year: 2003 PMID： 14680843 DOI： 10.1016/j.bbrc.2003.10.197
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575