Literature DB >> 14680811

Activation of the human alpha1(I) collagen promoter by leptin is not mediated by transforming growth factor beta responsive elements.

Mei Tang1, James J Potter, Esteban Mezey.   

Abstract

Leptin increases human alpha1 (I) collagen mRNA and type I collagen production and enhances hepatic fibrosis in animal models of hepatic fibrosis. These effects of leptin on fibrogenesis may be mediated by TGFbeta1, since leptin increases the TGFbeta type II receptor and augments the effect of TGFbeta1 on collagen production by stellate cells. In this study, leptin increased the activity of the human alpha1 (I) collagen promoter in transfected stellate cells. Leptin did not further enhance the activation of the promoter induced by TGFbeta1. Leptin had no effects on the transfected TGFbeta-responsive p3TP-LUX plasmid, which contains 3 CAGA elements that are essential and sufficient for the induction by TGFbeta. Leptin did not increase significantly the binding of proteins to two TGFbeta1 responsive elements in the human alpha1 (I) collagen promoter. In conclusion, this study shows that leptin activates the alpha1 (I) collagen gene and that this effect is not mediated by TGFbeta responsive elements.

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Year:  2003        PMID： 14680811     DOI： 10.1016/j.bbrc.2003.10.167

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  1,25-dihydroxyvitamin D3 and its nuclear receptor repress human α1 (I) collagen expression and type I collagen formation.

Authors:  James J Potter; Xiaopu Liu; Ayman Koteish; Esteban Mezey
Journal:  Liver Int       Date:  2013-02-17       Impact factor: 5.828

2.  Capsule oxymatrine in treatment of hepatic fibrosis due to chronic viral hepatitis: a randomized, double blind, placebo-controlled, multicenter clinical study.

Authors:  Yi-Min Mao; Min-De Zeng; Lun-Gen Lu; Mo-Bin Wan; Cheng-Zhong Li; Cheng-Wei Chen; Qing-Chuen Fu; Ji-Yao Wang; Wei-Min She; Xiong Cai; Jun Ye; Xia-Qiu Zhou; Hui Wang; Shan-Ming Wu; Mei-Fang Tang; Jin-Shui Zhu; Wei-Xiong Chen; Hui-Quan Zhang
Journal:  World J Gastroenterol       Date:  2004-11-15       Impact factor: 5.742

Review 3.  Extracellular matrix and liver disease.

Authors:  Elena Arriazu; Marina Ruiz de Galarreta; Francisco Javier Cubero; Marta Varela-Rey; María Pilar Pérez de Obanos; Tung Ming Leung; Aritz Lopategi; Aitor Benedicto; Ioana Abraham-Enachescu; Natalia Nieto
Journal:  Antioxid Redox Signal       Date:  2014-01-08       Impact factor: 8.401

4.  Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model.

Authors:  Swathi Karthikeyan; James J Potter; Jean-Francois Geschwind; Surojit Sur; James P Hamilton; Bert Vogelstein; Kenneth W Kinzler; Esteban Mezey; Shanmugasundaram Ganapathy-Kanniappan
Journal:  Biochem Biophys Res Commun       Date:  2015-10-23       Impact factor: 3.575

5.  Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors.

Authors:  Polina Sysa; James J Potter; Xiaopu Liu; Esteban Mezey
Journal:  DNA Cell Biol       Date:  2009-09       Impact factor: 3.311

6.  Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin.

Authors:  Priya Gajendiran; Leonel Iglesias Vega; Kie Itoh; Hiromi Sesaki; Mohammad Reza Vakili; Afsaneh Lavasanifar; Kelvin Hong; Esteban Mezey; Shanmugasundaram Ganapathy-Kanniappan
Journal:  J Cell Mol Med       Date:  2018-02-04       Impact factor: 5.310
  6 in total

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