Literature DB >> 14680212

The C-terminal ester of membrane anchored peptide ion channels affects anion transport.

Natasha Djedovic1, Riccardo Ferdani, Egan Harder, Jolanta Pajewska, Robert Pajewski, Paul H Schlesinger, George W Gokel.   

Abstract

Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.

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Year:  2003        PMID： 14680212     DOI： 10.1039/b312209n

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Fluorescent, synthetic amphiphilic heptapeptide anion transporters: evidence for self-assembly and membrane localization in liposomes.

Authors:  Lei You; George W Gokel
Journal:  Chemistry       Date:  2008       Impact factor: 5.236

2.  Planar bilayer studies reveal multiple conductance states for synthetic anion transporters.

Authors:  Riccardo Ferdani; George W Gokel
Journal:  Org Biomol Chem       Date:  2006-08-29       Impact factor: 3.876

3.  Evidence for dimer formation by an amphiphilic heptapeptide that mediates chloride and carboxyfluorescein release from liposomes.

Authors:  Robert Pajewski; Riccardo Ferdani; Jolanta Pajewska; Natasha Djedovic; Paul H Schlesinger; George W Gokel
Journal:  Org Biomol Chem       Date:  2005-01-13       Impact factor: 3.876

4.  Carboxylate anion diminishes chloride transport through a synthetic, self-assembled transmembrane pore.

Authors:  Lei You; Riccardo Ferdani; Ruiqiong Li; Joseph P Kramer; Rudolph Ernst K Winter; George W Gokel
Journal:  Chemistry       Date:  2008       Impact factor: 5.236

5.  Transport of chloride and carboxyfluorescein through phospholipid vesicle membranes by heptapeptide amphiphiles.

Authors:  Riccardo Ferdani; Ruiqiong Li; Robert Pajewski; Jolanta Pajewska; Rudolph K Winter; George W Gokel
Journal:  Org Biomol Chem       Date:  2007-06-25       Impact factor: 3.876

6.  Anion Transport in Liposomes Responds to Variations in the Anchor Chains and the Fourth Amino Acid of Heptapeptide Ion Channels.

Authors:  Riccardo Ferdani; Robert Pajewski; Natasha Djedovič; Jolanta Pajewska; Paul H Schlesinger; George W Gokel
Journal:  New J Chem       Date:  2005       Impact factor: 3.591
  6 in total

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