OBJECTIVE: Recent epidemiological and prospective trial evidence suggests that consumption of a low glycaemic index (LGI) diet will reduce coronary risk. We hypothesise that introduction of an LGI diet will improve the metabolic profile of patients who have undergone coronary artery bypass grafting. DESIGN: We conducted a randomised parallel group trial comparing a controlgroup (n=29, age 61.8+/-9 y), who received currently advocated healthy eating dietary advice only, to an intervention group, who receivedhealthy eating advice emphasising LGI carbohydrates (n=26, age 63.6+/-9.4 y) over a 12-week period in free-living patients with coronary heart disease. Outcome measures included fasting glucose, insulin, total cholesterol, high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, low density lipoprotein cholesterol and triglycerides. RESULTS: A significant lower dietary glycaemic index was achieved in the group assigned to an LGI diet compared to the healthy eating control group (71+/-1 vs 81+/-1); fibre intake was also higher in the LGI group (20+/-1 vs 15+/-1 g). All biochemical markers of glucose and lipid metabolism measured were similar after 12 weeks of the LGI diet or control diet. DISCUSSION: The LGI group achieved a significant LGI and a higher dietary fibre intake. However, there was no measurable significant effect of either the LGI diet or the health eating diet on lipid levels; this may have been hidden by concurrent drug therapy.
RCT Entities:
OBJECTIVE: Recent epidemiological and prospective trial evidence suggests that consumption of a low glycaemic index (LGI) diet will reduce coronary risk. We hypothesise that introduction of an LGI diet will improve the metabolic profile of patients who have undergone coronary artery bypass grafting. DESIGN: We conducted a randomised parallel group trial comparing a control group (n=29, age 61.8+/-9 y), who received currently advocated healthy eating dietary advice only, to an intervention group, who received healthy eating advice emphasising LGI carbohydrates (n=26, age 63.6+/-9.4 y) over a 12-week period in free-living patients with coronary heart disease. Outcome measures included fasting glucose, insulin, total cholesterol, high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, low density lipoprotein cholesterol and triglycerides. RESULTS: A significant lower dietary glycaemic index was achieved in the group assigned to an LGI diet compared to the healthy eating control group (71+/-1 vs 81+/-1); fibre intake was also higher in the LGI group (20+/-1 vs 15+/-1 g). All biochemical markers of glucose and lipid metabolism measured were similar after 12 weeks of the LGI diet or control diet. DISCUSSION: The LGI group achieved a significant LGI and a higher dietary fibre intake. However, there was no measurable significant effect of either the LGI diet or the health eating diet on lipid levels; this may have been hidden by concurrent drug therapy.
Authors: Rudolf Chlup; Pavel Seckar; Jana Zapletalová; Katerina Langová; Pavla Kudlová; Karolina Chlupová; Josef Bartek; Daniela Jelenová Journal: J Diabetes Sci Technol Date: 2008-01
Authors: Nicola M McKeown; James B Meigs; Simin Liu; Gail Rogers; Makiko Yoshida; Edward Saltzman; Paul F Jacques Journal: J Am Coll Nutr Date: 2009-04 Impact factor: 3.169
Authors: J L Sievenpiper; C W C Kendall; A Esfahani; J M W Wong; A J Carleton; H Y Jiang; R P Bazinet; E Vidgen; D J A Jenkins Journal: Diabetologia Date: 2009-06-13 Impact factor: 10.122
Authors: Christine Clar; Lena Al-Khudairy; Emma Loveman; Sarah Am Kelly; Louise Hartley; Nadine Flowers; Roberta Germanò; Gary Frost; Karen Rees Journal: Cochrane Database Syst Rev Date: 2017-07-31
Authors: Laura Chiavaroli; Cyril W C Kendall; Catherine R Braunstein; Sonia Blanco Mejia; Lawrence A Leiter; David J A Jenkins; John L Sievenpiper Journal: BMJ Open Date: 2018-04-02 Impact factor: 2.692