Literature DB >> 14679244

Identification of residues of the kid toxin involved in autoregulation of the parD system.

Marc Lemonnier1, Sandra Santos-Sierra, Consolación Pardo-Abarrio, Ramón Díaz-Orejas.   

Abstract

The toxin-antitoxin system parD (kis kid) of plasmid R1 is coregulated by the coordinated action of its two gene products. Here we describe the isolation and the in vivo characterization of three single-amino-acid changes in the Kid toxin, G4E, C74Y, and E91K, that affect the coregulatory activity but preserve the toxicity of the protein.

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Year:  2004        PMID： 14679244      PMCID： PMC303459          DOI： 10.1128/JB.186.1.240-243.2004

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  13 in total

Review 1.  Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress.

Authors:  K Gerdes
Journal:  J Bacteriol       Date:  2000-02       Impact factor: 3.490

2.  Genetic identification of two functional regions in the antitoxin of the parD killer system of plasmid R1.

Authors:  Sandra Santos-Sierra; Consolación Pardo-Abarrio; Rafael Giraldo; Ramón Díaz-Orejas
Journal:  FEMS Microbiol Lett       Date:  2002-01-02       Impact factor: 2.742

3.  Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition.

Authors:  Katsuhiko Kamada; Fumio Hanaoka; Stephen K Burley
Journal:  Mol Cell       Date:  2003-04       Impact factor: 17.970

4.  Non-cytotoxic variants of the Kid protein that retain their auto-regulatory activity.

Authors:  Sandra Santos-Sierra; Marc Lemonnier; Belen Nuñez; David Hargreaves; John Rafferty; Rafael Giraldo; Jose Manuel Andreu; Ramon Díaz-Orejas
Journal:  Plasmid       Date:  2003-09       Impact factor: 3.466

5.  The kis and kid genes of the parD maintenance system of plasmid R1 form an operon that is autoregulated at the level of transcription by the co-ordinated action of the Kis and Kid proteins.

Authors:  M J Ruiz-Echevarría; A Berzal-Herranz; K Gerdes; R Díaz-Orejas
Journal:  Mol Microbiol       Date:  1991-11       Impact factor: 3.501

6.  Use of T7 RNA polymerase to direct expression of cloned genes.

Authors:  F W Studier; A H Rosenberg; J J Dunn; J W Dubendorff
Journal:  Methods Enzymol       Date:  1990       Impact factor: 1.600

7.  Killing of Escherichia coli cells modulated by components of the stability system ParD of plasmid R1.

Authors:  A Bravo; S Ortega; G de Torrontegui; R Díaz
Journal:  Mol Gen Genet       Date:  1988-12

8.  Identification of components of a new stability system of plasmid R1, ParD, that is close to the origin of replication of this plasmid.

Authors:  A Bravo; G de Torrontegui; R Díaz
Journal:  Mol Gen Genet       Date:  1987-11

9.  Mutagenesis of plasmid DNA with hydroxylamine: isolation of mutants of multi-copy plasmids.

Authors:  G O Humphreys; G A Willshaw; H R Smith; E S Anderson
Journal:  Mol Gen Genet       Date:  1976-04-23

10.  Structural and functional analysis of the kid toxin protein from E. coli plasmid R1.

Authors:  David Hargreaves; Sandra Santos-Sierra; Rafael Giraldo; Rosario Sabariegos-Jareño; Guillermo de la Cueva-Méndez; Rolf Boelens; Ramon Díaz-Orejas; John B Rafferty
Journal:  Structure       Date:  2002-10       Impact factor: 5.006
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  5 in total

1.  Percolation of the phd repressor-operator interface.

Authors:  Xueyan Zhao; Roy David Magnuson
Journal:  J Bacteriol       Date:  2005-03       Impact factor: 3.490

2.  RNase/anti-RNase activities of the bacterial parD toxin-antitoxin system.

Authors:  Ana J Muñoz-Gómez; Marc Lemonnier; Sandra Santos-Sierra; Alfredo Berzal-Herranz; Ramón Díaz-Orejas
Journal:  J Bacteriol       Date:  2005-05       Impact factor: 3.490

3.  Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers.

Authors:  Maria C Monti; Ana M Hernández-Arriaga; Monique B Kamphuis; Juan López-Villarejo; Albert J R Heck; Rolf Boelens; Ramón Díaz-Orejas; Robert H H van den Heuvel
Journal:  Nucleic Acids Res       Date:  2007-02-21       Impact factor: 16.971

4.  Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression.

Authors:  Barbara Kedzierska; Lu-Yun Lian; Finbarr Hayes
Journal:  Nucleic Acids Res       Date:  2006-12-14       Impact factor: 16.971

5.  Coupling between the basic replicon and the Kis-Kid maintenance system of plasmid R1: modulation by Kis antitoxin levels and involvement in control of plasmid replication.

Authors:  Juan López-Villarejo; Damián Lobato-Márquez; Ramón Díaz-Orejas
Journal:  Toxins (Basel)       Date:  2015-02-05       Impact factor: 4.546
  5 in total

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