Literature DB >> 14679175

Tumbling down a different pathway to genetic instability.

Haiwei H Guo1, Lawrence A Loeb.   

Abstract

Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation.

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Year:  2003        PMID： 14679175      PMCID： PMC297004          DOI： 10.1172/JCI20502

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  18 in total

1.  Genetic instability and the mutator phenotype. Studies in ulcerative colitis.

Authors:  K R Loeb; L A Loeb
Journal:  Am J Pathol       Date:  1999-06       Impact factor: 4.307

2.  Passing the baton in base excision repair.

Authors:  S H Wilson; T A Kunkel
Journal:  Nat Struct Biol       Date:  2000-03

Review 3.  Polymorphisms in DNA repair and environmental interactions.

Authors:  Johan G de Boer
Journal:  Mutat Res       Date:  2002-11-30       Impact factor: 2.433

Review 4.  Polymorphisms in DNA repair genes and associations with cancer risk.

Authors:  Ellen L Goode; Cornelia M Ulrich; John D Potter
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2002-12       Impact factor: 4.254

5.  Induction of a low level of microsatellite instability by overexpression of DNA polymerase Beta.

Authors:  Nazumi A Yamada; Rosann A Farber
Journal:  Cancer Res       Date:  2002-11-01       Impact factor: 12.701

6.  Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia.

Authors:  A S Fleisher; M Esteller; G Tamura; A Rashid; O C Stine; J Yin; T T Zou; J M Abraham; D Kong; S Nishizuka; S P James; K T Wilson; J G Herman; S J Meltzer
Journal:  Oncogene       Date:  2001-01-18       Impact factor: 9.867

7.  Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia.

Authors:  R F Willenbucher; D E Aust; C G Chang; S J Zelman; L D Ferrell; D H Moore; F M Waldman
Journal:  Am J Pathol       Date:  1999-06       Impact factor: 4.307

8.  The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.

Authors:  John R Silber; Michael S Bobola; A Blank; Kathryn D Schoeler; Peter D Haroldson; Mary B Huynh; Douglas D Kolstoe
Journal:  Clin Cancer Res       Date:  2002-09       Impact factor: 12.531

Review 9.  Multiple mutations and cancer.

Authors:  Lawrence A Loeb; Keith R Loeb; Jon P Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-27       Impact factor: 11.205

10.  Oxidative stress inactivates the human DNA mismatch repair system.

Authors:  Christina L Chang; Giancarlo Marra; Dharam P Chauhan; Hannah T Ha; Dong K Chang; Luigi Ricciardiello; Ann Randolph; John M Carethers; C Richard Boland
Journal:  Am J Physiol Cell Physiol       Date:  2002-07       Impact factor: 4.249
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  8 in total

Review 1.  APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.

Authors:  Mark R Kelley; Millie M Georgiadis; Melissa L Fishel
Journal:  Curr Mol Pharmacol       Date:  2012-01       Impact factor: 3.339

2.  Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase.

Authors:  Joanna Klapacz; Gondichatnahalli M Lingaraju; Haiwei H Guo; Dharini Shah; Ayelet Moar-Shoshani; Lawrence A Loeb; Leona D Samson
Journal:  Mol Cell       Date:  2010-03-26       Impact factor: 17.970

3.  Gene expression profiles in peripheral blood mononuclear cells of ulcerative colitis patients.

Authors:  Ying-Lei Miao; Yu-Liang Xiao; Yan Du; Li-Ping Duan
Journal:  World J Gastroenterol       Date:  2013-06-07       Impact factor: 5.742

4.  Risk factors of colorectal cancer among Saudi Population: Case-control study.

Authors:  Mansour Z Alqahtani; Ashry G Mohammed; Awad S Alsamghan; Rishi K Bharti; Abdullah A Alsharm; Mohammed T Alshahrani; Mohammed A Alzahrani; Adil Ali N Ayed; Mohammed Abadi Alsaleem; Eisa Y Ghazwani
Journal:  J Family Med Prim Care       Date:  2020-09-30

5.  c-Myc-mediated genomic instability proceeds via a megakaryocytic endomitosis pathway involving Gp1balpha.

Authors:  Youjun Li; Jie Lu; Edward V Prochownik
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-20       Impact factor: 11.205

6.  Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells.

Authors:  Ranjit S Bindra; Paul J Schaffer; Alice Meng; Jennifer Woo; Kårstein Måseide; Matt E Roth; Paul Lizardi; David W Hedley; Robert G Bristow; Peter M Glazer
Journal:  Mol Cell Biol       Date:  2004-10       Impact factor: 4.272

7.  Colorectal cancer: a case control study of dietary factors, king faisal specialist hospital and researh center, riyadh, saudi arabia.

Authors:  Reem M Nashar; Khalid S Almurshed
Journal:  J Family Community Med       Date:  2008-05

8.  Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines.

Authors:  Dominik Wodarz; C Richard Boland; Ajay Goel; Natalia L Komarova
Journal:  Biol Direct       Date:  2013-06-11       Impact factor: 4.540
  8 in total

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