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Literature DB >> 14679172

Obesity-induced inflammatory changes in adipose tissue.

Kathryn E Wellen¹, Gokhan S Hotamisligil.

Abstract

Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.

Entities: Disease

Mesh：

Year: 2003 PMID： 14679172 PMCID： PMC297006 DOI： 10.1172/JCI20514

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

16 in total

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Authors: B S Rosen; K S Cook; J Yaglom; D L Groves; J E Volanakis; D Damm; T White; B M Spiegelman
Journal: Science Date: 1989-06-23 Impact factor: 47.728

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Authors: A Soukas; P Cohen; N D Socci; J M Friedman
Journal: Genes Dev Date: 2000-04-15 Impact factor: 11.361

5. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues.

Authors: J M Way; W W Harrington; K K Brown; W K Gottschalk; S S Sundseth; T A Mansfield; R K Ramachandran; T M Willson; S A Kliewer
Journal: Endocrinology Date: 2001-03 Impact factor: 4.736

6. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.

Authors: Liza Makowski; Jeffrey B Boord; Kazuhisa Maeda; Vladimir R Babaev; K Teoman Uysal; Maureen A Morgan; Rex A Parker; Jill Suttles; Sergio Fazio; Gökhan S Hotamisligil; MacRae F Linton
Journal: Nat Med Date: 2001-06 Impact factor: 53.440

7. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.

Authors: Haiyan Xu; Glenn T Barnes; Qing Yang; Guo Tan; Daseng Yang; Chieh J Chou; Jason Sole; Andrew Nichols; Jeffrey S Ross; Louis A Tartaglia; Hong Chen
Journal: J Clin Invest Date: 2003-12 Impact factor: 14.808

8. Obesity is associated with macrophage accumulation in adipose tissue.

Authors: Stuart P Weisberg; Daniel McCann; Manisha Desai; Michael Rosenbaum; Rudolph L Leibel; Anthony W Ferrante
Journal: J Clin Invest Date: 2003-12 Impact factor: 14.808

9. Preadipocyte conversion to macrophage. Evidence of plasticity.

Authors: Guillaume Charrière; Béatrice Cousin; Emmanuelle Arnaud; Mireille André; Francis Bacou; Luc Penicaud; Louis Casteilla
Journal: J Biol Chem Date: 2003-01-07 Impact factor: 5.157

10. Biological action of leptin as an angiogenic factor.

Authors: M R Sierra-Honigmann; A K Nath; C Murakami; G García-Cardeña; A Papapetropoulos; W C Sessa; L A Madge; J S Schechner; M B Schwabb; P J Polverini; J R Flores-Riveros
Journal: Science Date: 1998-09-11 Impact factor: 47.728

543 in total

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3. Escalator-driven research.

Authors: Friedrich C Luft
Journal: J Mol Med (Berl) Date: 2004-04-02 Impact factor: 4.599

Review 4. The potential of adipose stem cells in regenerative medicine.

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Journal: Stem Cell Rev Rep Date: 2011-06 Impact factor: 5.739

5. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.

Authors: Jonathon N Winnay; Jeremie Boucher; Marcelo A Mori; Kohjiro Ueki; C Ronald Kahn
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6. Foot pain severity is associated with the ratio of visceral to subcutaneous fat mass, fat-mass index and depression in women.

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Journal: Rheumatol Int Date: 2017-05-17 Impact factor: 2.631

Review 7. Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents.

Authors: Antonino Di Pino; Ralph A DeFronzo
Journal: Endocr Rev Date: 2019-12-01 Impact factor: 19.871

8. Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.

Authors: Olga Gealekman; Kunal Gurav; My Chouinard; Juerg Straubhaar; Michael Thompson; Samir Malkani; Celia Hartigan; Silvia Corvera
Journal: J Biol Chem Date: 2014-04-28 Impact factor: 5.157

Review 9. Inflammation, insulin resistance, and obesity.

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Review 10. Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions.

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