Literature DB >> 14677742

Benzocaine-induced methemoglobinemia: a potentially fatal complication of transesophageal echocardiography.

Rajesh Sachdeva1, Jaime G Pugeda, Linda R Casale, Jay L Meizlish, Stuart W Zarich.   

Abstract

We describe the cases of 2 patients who developed benzocaine-induced methemoglobinemia after the administration of benzocaine as premedication for transesophageal echocardiography. The use of intravenous methylene blue resolved the cyanosis in both patients. Physicians who perform procedures involving the application of topical anesthesia need to be aware of this side effect to prevent morbidity and mortality.

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Year:  2003        PMID： 14677742      PMCID： PMC307717     

Source DB:  PubMed          Journal:  Tex Heart Inst J        ISSN： 0730-2347


  12 in total

1.  Methemoglobinemia caused by topical benzocaine.

Authors:  S E Guerriero
Journal:  Pharmacotherapy       Date:  1997 Sep-Oct       Impact factor: 4.705

2.  Methemoglobinemia from perineal application of an anesthetic cream.

Authors:  M J Ferraro-Borgida; S A Mulhern; M O DeMeo; M J Bayer
Journal:  Ann Emerg Med       Date:  1996-06       Impact factor: 5.721

3.  Pharmacokinetics of highly ionized drugs. II. Methylene blue--absorption, metabolism, and excretion in man and dog after oral administration.

Authors:  A R DiSanto; J G Wagner
Journal:  J Pharm Sci       Date:  1972-07       Impact factor: 3.534

4.  Toxic methemoglobinemia after topical anesthesia for transesophageal echocardiography.

Authors:  S E Grauer; G D Giraud
Journal:  J Am Soc Echocardiogr       Date:  1996 Nov-Dec       Impact factor: 5.251

Review 5.  Drug-induced methaemoglobinaemia. Treatment issues.

Authors:  M D Coleman; N A Coleman
Journal:  Drug Saf       Date:  1996-06       Impact factor: 5.606

6.  Methemoglobinemia induced by local anesthetics.

Authors:  M L Olson; G K McEvoy
Journal:  Am J Hosp Pharm       Date:  1981-01

7.  Toxic methemoglobinemia caused by topical anesthetic given before transesophageal echocardiography.

Authors:  P A Marcovitz; B D Williamson; W F Armstrong
Journal:  J Am Soc Echocardiogr       Date:  1991 Nov-Dec       Impact factor: 5.251

8.  Benzocaine-induced methemoglobinemia--two case reports related to transesophageal echocardiography premedication.

Authors:  R T Ho; T Nanevicz; R Yee; V M Figueredo
Journal:  Cardiovasc Drugs Ther       Date:  1998-07       Impact factor: 3.727

9.  Benzocaine-induced methemoglobinemia during general anesthesia.

Authors:  F J Spielman; J A Anderson; W C Terry
Journal:  J Oral Maxillofac Surg       Date:  1984-11       Impact factor: 1.895

10.  Toxic methemoglobinemia: a rare but serious complication of transesophageal echocardiography.

Authors:  M A Fisher; D Henry; L Gillam; C Chen
Journal:  Can J Cardiol       Date:  1998-09       Impact factor: 5.223
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  5 in total

Review 1.  Topical anaesthesia for needle-related pain in newborn infants.

Authors:  Jann P Foster; Christine Taylor; Kaye Spence
Journal:  Cochrane Database Syst Rev       Date:  2017-02-04

2.  N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients.

Authors:  Nour Jalaleddine; Mahmood Hachim; Hamza Al-Hroub; Narjes Saheb Sharif-Askari; Abiola Senok; Adel Elmoselhi; Bassam Mahboub; Nimmi Moni Samuel Kurien; Richard K Kandasamy; Mohammad H Semreen; Rabih Halwani; Nelson C Soares; Saba Al Heialy
Journal:  Front Immunol       Date:  2022-05-19       Impact factor: 8.786

3.  Benzocaine-Induced Methemoglobinemia: A Case Report.

Authors:  Keith T Veltri; Ellen Rudnick
Journal:  P T       Date:  2016-03

4.  A computational perspective of molecular interactions through virtual screening, pharmacokinetic and dynamic prediction on ribosome toxin A chain and inhibitors of Ricinus communis.

Authors:  R Barani Kumar; M Xavier Suresh
Journal:  Pharmacognosy Res       Date:  2012-01

5.  A Rare Culprit of Methemoglobinemia.

Authors:  Kahtan Fadah; Miguel Rivera; Ajay Lingireddy; M Ammar Kalas; Reshad S Ghafouri; Abhizith Deoker
Journal:  J Investig Med High Impact Case Rep       Date:  2022 Jan-Dec
  5 in total

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