Literature DB >> 14677709

Microbial synthesis of (R)- and (S)-3,4-dimethoxyamphetamines through stereoselective transamination.

Akira Iwasaki1, Yukio Yamada, Yasuhiro Ikenaka, Junzo Hasegawa.   

Abstract

Two soil isolates, Arthrobactersp. KNK168 and Pseudomonas sp. KNK425, aminated 3,4-dimethoxyphenylacetone in presence of sec-butylamine as an amino donor to yield 3,4-dimethoxyamphetamine (DMA) with different enantioselectivities. The former gave (R)-DMA (>99% e.e.) and the latter the (S)-isomer (>99% e.e.).

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Year:  2003        PMID: 14677709     DOI: 10.1023/a:1026229610628

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN: 0141-5492            Impact factor:   2.461


  6 in total

1.  Rational assignment of key motifs for function guides in silico enzyme identification.

Authors:  Matthias Höhne; Sebastian Schätzle; Helge Jochens; Karen Robins; Uwe T Bornscheuer
Journal:  Nat Chem Biol       Date:  2010-09-26       Impact factor: 15.040

2.  Transaminases for the synthesis of enantiopure beta-amino acids.

Authors:  Jens Rudat; Birgit R Brucher; Christoph Syldatk
Journal:  AMB Express       Date:  2012-01-31       Impact factor: 3.298

3.  A new target region for changing the substrate specificity of amine transaminases.

Authors:  Li-Jun Guan; Jun Ohtsuka; Masahiko Okai; Takuya Miyakawa; Tomoko Mase; Yuehua Zhi; Feng Hou; Noriyuki Ito; Akira Iwasaki; Yoshihiko Yasohara; Masaru Tanokura
Journal:  Sci Rep       Date:  2015-06-01       Impact factor: 4.379

Review 4.  Transaminases for industrial biocatalysis: novel enzyme discovery.

Authors:  Stephen A Kelly; Stefan Mix; Thomas S Moody; Brendan F Gilmore
Journal:  Appl Microbiol Biotechnol       Date:  2020-04-16       Impact factor: 4.813

5.  Multi-enzyme pyruvate removal system to enhance (R)-selective reductive amination of ketones.

Authors:  Jinhua Zhang; Yanshu Zhao; Chao Li; Hao Song
Journal:  RSC Adv       Date:  2020-08-05       Impact factor: 4.036

6.  Transaminase-mediated synthesis of enantiopure drug-like 1-(3',4'-disubstituted phenyl)propan-2-amines.

Authors:  Ágnes Lakó; Zsófia Molnár; Ricardo Mendonça; László Poppe
Journal:  RSC Adv       Date:  2020-11-10       Impact factor: 4.036

  6 in total

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