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Literature DB >> 14676995

Innovations in pharmacotherapy for stress urinary incontinence.

Tracy W Cannon¹, Naoki Yoshimura, Michael B Chancellor.

Abstract

The purpose of this review article is to highlight new pharmacotherapies on the horizon for the treatment of stress urinary incontinence (SUI). Although behavioral and surgical therapies are currently the mainstay of treating SUI, we believe that medications will take center stage and possibly become first-line therapy. Currently, there are no FDA medications indicated for SUI. However, results are becoming available about an oral medication, duloxetine, which appears to be clinically safe and efficacious for the treatment of SUI. In addition to discussing medications currently under development, we will also discuss exciting pharmacological targets that could be suitable to treat SUI.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2003 PMID： 14676995 DOI： 10.1007/s00192-003-1093-9

Source DB: PubMed Journal: Int Urogynecol J Pelvic Floor Dysfunct

35 in total

1. Spinal 5-HT2 receptor-mediated facilitation of pudendal nerve reflexes in the anaesthetized cat.

Authors: H Danuser; K B Thor
Journal: Br J Pharmacol Date: 1996-05 Impact factor: 8.739

2. Changes in vesical neck mobility following vaginal delivery.

Authors: U Peschers; G Schaer; C Anthuber; J O Delancey; B Schuessler
Journal: Obstet Gynecol Date: 1996-12 Impact factor: 7.661

3. Pelvic floor damage and childbirth: a neurophysiological study.

Authors: R E Allen; G L Hosker; A R Smith; D W Warrell
Journal: Br J Obstet Gynaecol Date: 1990-09

4. Effect of pelvic muscle exercise on transient incontinence during pregnancy and after birth.

Authors: C M Sampselle; J M Miller; B L Mims; J O Delancey; J A Ashton-Miller; C L Antonakos
Journal: Obstet Gynecol Date: 1998-03 Impact factor: 7.661

5. Annual direct cost of urinary incontinence.

Authors: L Wilson; J S Brown; G P Shin; K O Luc; L L Subak
Journal: Obstet Gynecol Date: 2001-09 Impact factor: 7.661

6. Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine.

Authors: K B Thor; T Hisamitsu; W C de Groat
Journal: Brain Res Dev Brain Res Date: 1990-06-01

7. Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats.

Authors: Mary A Katofiasc; Jeffrey Nissen; James E Audia; Karl B Thor
Journal: Life Sci Date: 2002-08-02 Impact factor: 5.037

8. Experimental evidence for a central nervous system site of action in the effect of alpha-adrenergic blockers on the external urinary sphincter.

Authors: J Gajewski; J W Downie; S A Awad
Journal: J Urol Date: 1984-08 Impact factor: 7.450

9. The effects of birth on urinary continence mechanisms and other pelvic-floor characteristics.

Authors: S Meyer; A Schreyer; P De Grandi; P Hohlfeld
Journal: Obstet Gynecol Date: 1998-10 Impact factor: 7.661

10. Inhibition of central sympathetic and somatic outflow to the lower urinary tract of the cat by the alpha 1 adrenergic receptor antagonist prazosin.

Authors: H Danuser; K B Thor
Journal: J Urol Date: 1995-04 Impact factor: 7.450

5 in total

Innovations in pharmacotherapy for stress urinary incontinence.

1. Spinal 5-HT2 receptor-mediated facilitation of pudendal nerve reflexes in the anaesthetized cat.

2. Changes in vesical neck mobility following vaginal delivery.

3. Pelvic floor damage and childbirth: a neurophysiological study.

4. Effect of pelvic muscle exercise on transient incontinence during pregnancy and after birth.

5. Annual direct cost of urinary incontinence.

6. Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine.

7. Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats.

8. Experimental evidence for a central nervous system site of action in the effect of alpha-adrenergic blockers on the external urinary sphincter.

9. The effects of birth on urinary continence mechanisms and other pelvic-floor characteristics.

10. Inhibition of central sympathetic and somatic outflow to the lower urinary tract of the cat by the alpha 1 adrenergic receptor antagonist prazosin.

Review 1. Neural control of the lower urinary tract.

2. Neurophysiology of stress urinary incontinence.

3. Two kinds of urinary continence reflexes during abrupt elevation of intravesical pressure in rats.

Review 4. Medical management of stress urinary incontinence: is there a future?

Review 5. Therapeutic receptor targets for lower urinary tract dysfunction.