BACKGROUND: Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype, which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase (PTK) fyn knockout mice. METHODS: We performed an association study of genetic variations of PTK fyn in 430 alcohol-dependent patients and 365 unrelated control subjects from two independent samples. RESULTS: In a combined analysis, we found an association of alcohol dependence with the single nucleotide polymorphism (SNP) T137346C in the 5' untranslated region (UTR) of the gene. A relevant association could be excluded for the remaining two informative SNPs. Selection by phenotype showed that a high number of withdrawal symptoms, high amount of alcohol intake, and high maximum number of drinks compared with unrelated control subjects was associated with the SNP in the 5'-UTR region but not with the remaining SNPs. CONCLUSIONS: Our results indicate a possible association of alcohol dependence with a genotype of the SNP T137346C of the PTK fyn, with C being the risk allele.
BACKGROUND: Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype, which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase (PTK) fyn knockout mice. METHODS: We performed an association study of genetic variations of PTKfyn in 430 alcohol-dependent patients and 365 unrelated control subjects from two independent samples. RESULTS: In a combined analysis, we found an association of alcohol dependence with the single nucleotide polymorphism (SNP) T137346C in the 5' untranslated region (UTR) of the gene. A relevant association could be excluded for the remaining two informative SNPs. Selection by phenotype showed that a high number of withdrawal symptoms, high amount of alcohol intake, and high maximum number of drinks compared with unrelated control subjects was associated with the SNP in the 5'-UTR region but not with the remaining SNPs. CONCLUSIONS: Our results indicate a possible association of alcohol dependence with a genotype of the SNP T137346C of the PTKfyn, with C being the risk allele.
Authors: Shizhong Han; Bao-Zhu Yang; Henry R Kranzler; Xiaoming Liu; Hongyu Zhao; Lindsay A Farrer; Eric Boerwinkle; James B Potash; Joel Gelernter Journal: Am J Hum Genet Date: 2013-11-21 Impact factor: 11.025
Authors: Ming-Chyi Huang; Melanie L Schwandt; Julia A Chester; Aaron M Kirchhoff; Chung-Feng Kao; Tiebing Liang; Jenica D Tapocik; Vijay A Ramchandani; David T George; Colin A Hodgkinson; David Goldman; Markus Heilig Journal: Neuropsychopharmacology Date: 2014-03-07 Impact factor: 7.853