Literature DB >> 14675786

Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation.

Joris Hoeks1, Matthijs K C Hesselink, Marc van Bilsen, Gert Schaart, Ger J van der Vusse, Wim H M Saris, Patrick Schrauwen.   

Abstract

We compared UCP3 protein in rat cardiac, glycolytic and oxidative skeletal muscle and examined the effect of high-fat medium chain vs. long chain triacylglycerol feeding on UCP3 content in these tissues. Cardiac muscle displays the lowest basal levels of UCP3 protein. Increasing long chain - but not medium chain - fatty acid supply upregulates UCP3 in all muscles. Since plasma non-esterified fatty acids and the expression of two peroxisome proliferator-activated receptor (PPAR)-responsive genes, were not different between groups, we conclude that the differential upregulation of UCP3 is not merely PPAR-mediated. This study supports a role of UCP3 in export of non-metabolizable fatty acids.

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Year:  2003        PMID： 14675786     DOI： 10.1016/s0014-5793(03)01343-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Gene expression survey of mitochondrial uncoupling proteins (UCP1/UCP3) in gilthead sea bream (Sparus aurata L.).

Authors:  Azucena Bermejo-Nogales; Josep Alvar Calduch-Giner; Jaume Pérez-Sánchez
Journal:  J Comp Physiol B       Date:  2010-01-09       Impact factor: 2.200

2.  Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3.

Authors:  S McBride; L Wei-LaPierre; F McMurray; M MacFarlane; X Qiu; D A Patten; R T Dirksen; M-E Harper
Journal:  Arch Biochem Biophys       Date:  2019-01-16       Impact factor: 4.013

Review 3.  Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart.

Authors:  Alexander T Akhmedov; Vitalyi Rybin; José Marín-García
Journal:  Heart Fail Rev       Date:  2015-03       Impact factor: 4.214

Review 4.  Endothelial mitochondria--less respiration, more integration.

Authors:  Lukas N Groschner; Markus Waldeck-Weiermair; Roland Malli; Wolfgang F Graier
Journal:  Pflugers Arch       Date:  2012-03-01       Impact factor: 3.657

5.  Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle.

Authors:  Silvie Timmers; Johan de Vogel-van den Bosch; Matthijs K C Hesselink; Denis van Beurden; Gert Schaart; Maria Joao Ferraz; Mario Losen; Pilar Martinez-Martinez; Marc H De Baets; Johannes M F G Aerts; Patrick Schrauwen
Journal:  PLoS One       Date:  2011-01-14       Impact factor: 3.240

6.  Dietary long-chain, but not medium-chain, triglycerides impair exercise performance and uncouple cardiac mitochondria in rats.

Authors:  Andrew J Murray; Nicholas S Knight; Sarah E Little; Lowri E Cochlin; Mary Clements; Kieran Clarke
Journal:  Nutr Metab (Lond)       Date:  2011-08-01       Impact factor: 4.169

7.  Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner.

Authors:  Yolanda Gómez-Pérez; Gabriela Capllonch-Amer; Magdalena Gianotti; Isabel Lladó; Ana M Proenza
Journal:  Nutr Metab (Lond)       Date:  2012-02-21       Impact factor: 4.169

8.  Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

Authors:  Heiko Bugger; Sihem Boudina; Xiao Xuan Hu; Joseph Tuinei; Vlad G Zaha; Heather A Theobald; Ui Jeong Yun; Alfred P McQueen; Benjamin Wayment; Sheldon E Litwin; E Dale Abel
Journal:  Diabetes       Date:  2008-08-04       Impact factor: 9.461
  8 in total

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