Literature DB >> 14674607

Neuropeptides: general characteristics and neuropharmaceutical potential in treating CNS disorders.

Fleur L Strand1.   

Abstract

The general characteristics of neuropeptides are discussed as a background for the understanding of their role in regulation of physiological systems. The extent of those systems that are crucially affected by neuropeptides is vast and the complexity of their interactions makes the clinical focus on a specific neuropeptide unsatisfactory. The clinical potential of neuropeptides affecting eating disorders, CNS behavioral disorders and the neuroregenerative and neuroprotective action of neuropeptides is discussed. It is probable that successful neuropeptide therapeutics will depend upon the application of translational and combinational research using various ingenious combinations of neuropeptides, their agonists and antagonists, neuropeptide receptor agonists and antagonists, improved methods of delivery and the development of peptides targeted to the genetic profile of individual patients.

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Year:  2003        PMID: 14674607     DOI: 10.1007/978-3-0348-8049-7_1

Source DB:  PubMed          Journal:  Prog Drug Res        ISSN: 0071-786X


  30 in total

Review 1.  Neuropeptide-processing enzymes: applications for drug discovery.

Authors:  Lloyd D Fricker
Journal:  AAPS J       Date:  2005-10-05       Impact factor: 4.009

Review 2.  Processing of peptide and hormone precursors at the dibasic cleavage sites.

Authors:  Mohamed Rholam; Christine Fahy
Journal:  Cell Mol Life Sci       Date:  2009-03-20       Impact factor: 9.261

3.  Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.

Authors:  Kirill O Eremin; Vladimir S Kudrin; Pirjo Saransaari; Simo S Oja; Igor A Grivennikov; Nikolay F Myasoedov; Kirill S Rayevsky
Journal:  Neurochem Res       Date:  2005-12       Impact factor: 3.996

Review 4.  Orphan neuropeptides and receptors: Novel therapeutic targets.

Authors:  Lloyd D Fricker; Lakshmi A Devi
Journal:  Pharmacol Ther       Date:  2017-11-22       Impact factor: 12.310

5.  Peptidomic analyses of mouse astrocytic cell lines and rat primary cultured astrocytes.

Authors:  Ping Yin; Ann M Knolhoff; Harry J Rosenberg; Larry J Millet; Martha U Gillette; Jonathan V Sweedler
Journal:  J Proteome Res       Date:  2012-07-16       Impact factor: 4.466

6.  Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior.

Authors:  Galyna Sidyelyeva; Christian Wegener; Brian P Schoenfeld; Aaron J Bell; Nicholas E Baker; Sean M J McBride; Lloyd D Fricker
Journal:  Cell Mol Life Sci       Date:  2010-04-13       Impact factor: 9.261

7.  Mass spectrometric evaluation of neuropeptidomic profiles upon heat stabilization treatment of neuroendocrine tissues in crustaceans.

Authors:  Robert M Sturm; Tyler Greer; Nicole Woodards; Erin Gemperline; Lingjun Li
Journal:  J Proteome Res       Date:  2013-01-02       Impact factor: 4.466

8.  Rat brain neuropeptidomics: tissue collection, protease inhibition, neuropeptide extraction, and mass spectrometric analysis.

Authors:  Robert M Sturm; James A Dowell; Lingjun Li
Journal:  Methods Mol Biol       Date:  2010

9.  Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice.

Authors:  Ramona M Rodriguiz; John J Wilkins; Thomas K Creson; Reeta Biswas; Iryna Berezniuk; Arun D Fricker; Lloyd D Fricker; William C Wetsel
Journal:  Int J Neuropsychopharmacol       Date:  2013-02-27       Impact factor: 5.176

Review 10.  Microfluidic systems for studying neurotransmitters and neurotransmission.

Authors:  Callie A Croushore; Jonathan V Sweedler
Journal:  Lab Chip       Date:  2013-05-07       Impact factor: 6.799

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