Literature DB >> 14673208

Cyclin-dependent kinase 5 in amyotrophic lateral sclerosis.

Minh Dang Nguyen1, Jean-Pierre Julien.   

Abstract

Amyotrophic lateral sclerosis is a neurological disorder that selectively affects motor neurons of brain and spinal cord. Emerging evidence indicates an involvement of the serine/threonine-cyclin-dependent kinase 5 (Cdk5) in the pathogenesis. Deregulation of Cdk5 by its truncated co-activators, p25 and p29, contributes to neurodegeneration by altering the phosphorylation state of cytosolic and cytoskeletal proteins and, possibly, through the induction of cell cycle regulators. The present paper reviews these findings and proposes new perspectives to decipher the mechanisms of neurodegeneration in amyotrophic lateral sclerosis induced by Cdk5. Copyright 2003 S. Karger AG, Basel

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Year:  2003        PMID： 14673208     DOI： 10.1159/000074623

Source DB:  PubMed          Journal:  Neurosignals        ISSN： 1424-862X


  25 in total

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2.  Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.

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3.  Mechanism of CDK5 activation revealed by steered molecular dynamics simulations and energy calculations.

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Journal:  J Mol Model       Date:  2009-12-15       Impact factor: 1.810

4.  Docking and 3D-QSAR modeling of cyclin-dependent kinase 5/p25 inhibitors.

Authors:  Zaheer Ul Haq; Reaz Uddin; Lam Kok Wai; Abdul Wadood; Nordin Haji Lajis
Journal:  J Mol Model       Date:  2010-08-05       Impact factor: 1.810

5.  Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer's Disease.

Authors:  Jeyapriya Raja Sundaram; Charlene Priscilla Poore; Noor Hazim Bin Sulaimee; Tej Pareek; Wei Fun Cheong; Markus R Wenk; Harish C Pant; Sally A Frautschy; Chian-Ming Low; Sashi Kesavapany
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

6.  Study of the inhibition of cyclin-dependent kinases with roscovitine and indirubin-3'-oxime from molecular dynamics simulations.

Authors:  Bing Zhang; Vincent B C Tan; Kian Meng Lim; Tong Earn Tay; Shulin Zhuang
Journal:  J Mol Model       Date:  2006-06-13       Impact factor: 1.810

7.  Molecular dynamics simulations on the inhibition of cyclin-dependent kinases 2 and 5 in the presence of activators.

Authors:  Bing Zhang; Vincent B C Tan; Kian Meng Lim; Tong Earn Tay
Journal:  J Comput Aided Mol Des       Date:  2006-10-13       Impact factor: 3.686

Review 8.  Selectivity and potency of cyclin-dependent kinase inhibitors.

Authors:  Jayalakshmi Sridhar; Nagaraju Akula; Nagarajan Pattabiraman
Journal:  AAPS J       Date:  2006-03-24       Impact factor: 4.009

9.  Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.

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Journal:  J Neurosci       Date:  2009-10-07       Impact factor: 6.167

10.  Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.

Authors:  Mala V Rao; Mary Kate McBrayer; Jabbar Campbell; Asok Kumar; Audrey Hashim; Henry Sershen; Philip H Stavrides; Masuo Ohno; Michael Hutton; Ralph A Nixon
Journal:  J Neurosci       Date:  2014-07-09       Impact factor: 6.167
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