Literature DB >> 14672535

Secrets of insulin and IGF-1 regulation of insulin secretion revealed.

Peter R Shepherd1.   

Abstract

There has been ongoing controversy over the respective roles of insulin-like growth factor-1 receptors and insulin receptors in controlling insulin release from beta-cells of the pancreas. An acute knock-down experiment exploiting small interfering RNA approaches provides a resolution: both are required.

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Year:  2004        PMID: 14672535      PMCID: PMC1223857          DOI: 10.1042/BJ20031747

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  2 in total

1.  Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells.

Authors:  K Raile; J Klammt; S Laue; A Garten; M Blüher; S Kralisch; N Klöting; W Kiess
Journal:  Diabetologia       Date:  2005-07-29       Impact factor: 10.122

2.  Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1.

Authors:  Mi Jin Moon; Hee Young Kim; Sumi Park; Dong-Kyu Kim; Eun Bee Cho; Jong-Ik Hwang; Jae Young Seong
Journal:  Mol Cells       Date:  2011-09-07       Impact factor: 5.034

  2 in total

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