Literature DB >> 1467141

Stereoselective inhibition of renal organic cation transport in human kidney.

L T Wong1, D D Smyth, D S Sitar.   

Abstract

Amantadine was found to be concentrated by human cortical slices, with apparent Km and Vmax values of 187 +/- 11 microM and 1.37 +/- 0.28 nmol mg-1 min-1 respectively (mean +/- s.e. mean, n = 4). Addition of quinine (8S, 9R-(-)-isomer) or quinidine (8R, 9S-(+)-isomer) competitively inhibited this accumulation (apparent Ki values of 261 +/- 44 (n = 4) and 586 +/- 68 microM (n = 3), respectively). The stereoselectivity of this inhibition is the reverse of that seen with respect to the renal clearances of the diastereoisomers.

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Year:  1992        PMID： 1467141      PMCID： PMC1381475          DOI： 10.1111/j.1365-2125.1992.tb05653.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  9 in total

1.  Statistical estimations in enzyme kinetics.

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5.  Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.

Authors:  S V Otton; H K Crewe; M S Lennard; G T Tucker; H F Woods
Journal:  J Pharmacol Exp Ther       Date:  1988-10       Impact factor: 4.030

6.  Human tissues in biomedical research.

Authors:  B F Trump; C C Harris
Journal:  Hum Pathol       Date:  1979-05       Impact factor: 3.466

7.  Stereoselective inhibition of amantadine accumulation by quinine and quinidine in rat renal proximal tubules and cortical slices.

Authors:  L T Wong; D D Smyth; D S Sitar
Journal:  J Pharmacol Exp Ther       Date:  1990-10       Impact factor: 4.030

8.  Interference with renal organic cation transport by (-)- and (+)-nicotine at concentrations documented in plasma of habitual tobacco smokers.

Authors:  L T Wong; D D Smyth; D S Sitar
Journal:  J Pharmacol Exp Ther       Date:  1992-04       Impact factor: 4.030

9.  Stereoselective renal tubular secretion of quinidine and quinine.

Authors:  D A Notterman; D E Drayer; L Metakis; M M Reidenberg
Journal:  Clin Pharmacol Ther       Date:  1986-11       Impact factor: 6.875
  9 in total
  2 in total

Review 1.  Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs.

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2.  Structure and interaction of inhibitors with the TEA/H+ exchanger of rabbit renal brush border membranes.

Authors:  S H Wright; T M Wunz; T P Wunz
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  2 in total

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