| Literature DB >> 1467139 |
J J Schneider1, P J Ravenscroft, J D Cavenagh, A M Brown, J P Bradley.
Abstract
Plasma morphine concentrations were measured in five cancer patients receiving long-term epidural morphine administration. Peak concentrations were observed within 1 h of dosage and concentrations then declined biexponentially. Plasma morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) concentrations were measured in two patients and plasma M3G concentrations were observed to be much higher than plasma M6G and morphine concentrations. Peak plasma M6G concentrations occurred within 1.0 h of dosing and plasma M6G concentrations then remained higher than plasma morphine concentrations.Entities:
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Year: 1992 PMID： 1467139 PMCID： PMC1381473 DOI： 10.1111/j.1365-2125.1992.tb05651.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335