Literature DB >> 14670596

Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells.

Nathalie Dereuddre-Bosquet1, Béatrice Roy, Kate Routledge, Pascal Clayette, Georges Foucault, Michel Lepoivre.   

Abstract

Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.

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Year:  2004        PMID： 14670596     DOI： 10.1016/j.antiviral.2003.08.002

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  8 in total

1.  Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases.

Authors:  Jessica A Brown; Lindsey R Pack; Jason D Fowler; Zucai Suo
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

2.  Mechanisms of product feedback regulation and drug resistance in cytidine triphosphate synthetases from the structure of a CTP-inhibited complex.

Authors:  James A Endrizzi; Hanseong Kim; Paul M Anderson; Enoch P Baldwin
Journal:  Biochemistry       Date:  2005-10-18       Impact factor: 3.162

3.  Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy.

Authors:  Petri Kursula; Susanne Flodin; Maria Ehn; Martin Hammarström; Herwig Schüler; Pär Nordlund; Pål Stenmark
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-06-10

4.  Phosphorylation of human CTP synthetase 1 by protein kinase A: identification of Thr455 as a major site of phosphorylation.

Authors:  Mal-Gi Choi; George M Carman
Journal:  J Biol Chem       Date:  2006-12-22       Impact factor: 5.157

5.  Phosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylation.

Authors:  Yu-Fang Chang; Shelley S Martin; Enoch P Baldwin; George M Carman
Journal:  J Biol Chem       Date:  2007-04-26       Impact factor: 5.157

6.  Crystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targets.

Authors:  James A Endrizzi; Hanseong Kim; Paul M Anderson; Enoch P Baldwin
Journal:  Biochemistry       Date:  2004-06-01       Impact factor: 3.162

Review 7.  CTP synthase: the hissing of the cellular serpent.

Authors:  Shallinie Thangadurai; Morteza Bajgiran; Sharvin Manickam; Nethia Mohana-Kumaran; Ghows Azzam
Journal:  Histochem Cell Biol       Date:  2022-07-26       Impact factor: 2.531

8.  Structural basis for isoform-specific inhibition of human CTPS1.

Authors:  Eric M Lynch; Michael A DiMattia; Steven Albanese; Gydo C P van Zundert; Jesse M Hansen; Joel D Quispe; Madison A Kennedy; Andreas Verras; Kenneth Borrelli; Angela V Toms; Neelu Kaila; Kevin D Kreutter; Joshua J McElwee; Justin M Kollman
Journal:  Proc Natl Acad Sci U S A       Date:  2021-10-05       Impact factor: 11.205
  8 in total

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