Literature DB >> 14670347

Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines.

Bavesh D Kana1, Valerie Mizrahi.   

Abstract

Genetic systems that allow mycobacterial genomes to be mutagenized in a targeted or random fashion have provided the means for developing new tools for the diagnosis, prevention and treatment of tuberculosis by allowing potential targets to be identified and validated. In this review, we highlight key historical developments in the field of mycobacterial genetics, which have yielded the powerful repertoire of genetic tools that are now in hand and provide examples that illustrate their use in exploring specific aspects of mycobacterial metabolism.

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Year:  2004        PMID： 14670347     DOI： 10.1016/j.tube.2003.08.006

Source DB:  PubMed          Journal:  Tuberculosis (Edinb)        ISSN： 1472-9792            Impact factor:   3.131


  6 in total

1.  Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator.

Authors:  Malini Rajagopalan; Renata Dziedzic; Maha Al Zayer; Dorota Stankowska; Marie-Claude Ouimet; D Patrick Bastedo; Gregory T Marczynski; Murty V Madiraju
Journal:  J Biol Chem       Date:  2010-03-11       Impact factor: 5.157

Review 2.  Physiology of mycobacteria.

Authors:  Gregory M Cook; Michael Berney; Susanne Gebhard; Matthias Heinemann; Robert A Cox; Olga Danilchanka; Michael Niederweis
Journal:  Adv Microb Physiol       Date:  2009       Impact factor: 3.517

3.  Functional expression of the Flp recombinase in Mycobacterium bovis BCG.

Authors:  Houhui Song; Michael Niederweis
Journal:  Gene       Date:  2007-05-21       Impact factor: 3.688

4.  Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatis.

Authors:  David Patrick Kateete; Fred Ashaba Katabazi; Alfred Okeng; Moses Okee; Conrad Musinguzi; Benon Byamugisha Asiimwe; Samuel Kyobe; Jeniffer Asiimwe; W Henry Boom; Moses Lutaakome Joloba
Journal:  PLoS One       Date:  2012-09-21       Impact factor: 3.240

5.  Life without dUTPase.

Authors:  Csaba Kerepesi; Judit E Szabó; Veronika Papp-Kádár; Orsolya Dobay; Dóra Szabó; Vince Grolmusz; Beáta G Vértessy
Journal:  Front Microbiol       Date:  2016-11-14       Impact factor: 5.640

6.  GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism.

Authors:  Dany J V Beste; Tracy Hooper; Graham Stewart; Bhushan Bonde; Claudio Avignone-Rossa; Michael E Bushell; Paul Wheeler; Steffen Klamt; Andrzej M Kierzek; Johnjoe McFadden
Journal:  Genome Biol       Date:  2007       Impact factor: 13.583
  6 in total

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