| Literature DB >> 14670334 |
Martin O C Ota1, Johan Vekemans, Susanna E Schlegel-Haueter, Katherine Fielding, Hilton Whittle, Paul Henri Lambert, Keith P W J McAdam, Claire Anne Siegrist, Arnaud Marchant.
Abstract
New-borns raise limited antibody responses to most T cell-dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new-borns and nai;ve adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-gamma responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults.Entities:
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Year: 2004 PMID： 14670334 DOI： 10.1016/j.vaccine.2003.07.020
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641