UNLABELLED: Intrauterine growth restriction is connected with high rate of prematurity and perinatal mortality. 8-isoprostane is one of the oxidative stress indices, similar to the prostaglandins and connected with vessels restriction. The main aim of the study was to find the correlation between the L-arginine and acetylsalicylic acid therapy and 8-isoprostane concentration. MATERIAL AND METHODS: The study was done in Dep. of Obstetrics and Gynaecology Medical University in Lodz in 2000-2002 y. The study group consist of 50 women with diagnosed IUGR, the controls: 30 healthy pregnant women at the same gestational age. The IUGR therapy consisted of L-arginine 3 x 1 g and acetylsalicylic acid--Acard 1 x 1 daily. 8-isoprostane was measured in maternal blood in first and 20-th day of observation. The Oxis Immunoassay for 8-epi prostaglandin was used. The results were expressed in ng/ml of serum. RESULTS: The concentration of 8-isoprostane at the first day of observation in women with IUGR was 0.0587 ng/ml, and after 20 days decreased to 0.0569. In women in normal pregnancy at the first day was 0.0539 ng/ml and after 20 days 0.0547 ng/ml. CONCLUSIONS: The 8-isoprostane concentration increased in blood serum due to the pregnancy duration. The therapeutic method decreased the concentration of this oxidative stress marker.
UNLABELLED: Intrauterine growth restriction is connected with high rate of prematurity and perinatal mortality. 8-isoprostane is one of the oxidative stress indices, similar to the prostaglandins and connected with vessels restriction. The main aim of the study was to find the correlation between the L-arginine and acetylsalicylic acid therapy and 8-isoprostane concentration. MATERIAL AND METHODS: The study was done in Dep. of Obstetrics and Gynaecology Medical University in Lodz in 2000-2002 y. The study group consist of 50 women with diagnosed IUGR, the controls: 30 healthy pregnant women at the same gestational age. The IUGR therapy consisted of L-arginine 3 x 1 g and acetylsalicylic acid--Acard 1 x 1 daily. 8-isoprostane was measured in maternal blood in first and 20-th day of observation. The Oxis Immunoassay for 8-epi prostaglandin was used. The results were expressed in ng/ml of serum. RESULTS: The concentration of 8-isoprostane at the first day of observation in women with IUGR was 0.0587 ng/ml, and after 20 days decreased to 0.0569. In women in normal pregnancy at the first day was 0.0539 ng/ml and after 20 days 0.0547 ng/ml. CONCLUSIONS: The 8-isoprostane concentration increased in blood serum due to the pregnancy duration. The therapeutic method decreased the concentration of this oxidative stress marker.