Qing Gui1, Gui-sheng Qian, Gui-jun Huang, Shu-ping Li. 1. Respiration Institute of Xinqiao Hospital, the Third Military Medical University, Chongqing, 400037 PR China. qinggui3472@sina.com.cn
Abstract
OBJECTIVE: To investigate the possible association between polymorphism of CC16 gene exon 1 and asthma, the genotype and allele frequencies of CC16 gene exon 1 in the asthmatic patients of Han population in southwest China were analyzed. METHODS: The authors determined the genotypes of CC16 gene exon 1 with polymerase chain reaction technique and restricted enzyme analysis, and then compared the genotype and allele frequencies of the gene of the asthmatic group with those of the healthy control group. RESULTS: There was no significant difference in genotype and allele frequencies of CC16 gene between the asthmatic group and control group. There was no association between the genotype and allele frequencies of gene and the severity of asthma. CONCLUSION: CC16 gene may be not a susceptibility gene of asthmatic patients of Han population in southwest China.
OBJECTIVE: To investigate the possible association between polymorphism of CC16 gene exon 1 and asthma, the genotype and allele frequencies of CC16 gene exon 1 in the asthmatic patients of Han population in southwest China were analyzed. METHODS: The authors determined the genotypes of CC16 gene exon 1 with polymerase chain reaction technique and restricted enzyme analysis, and then compared the genotype and allele frequencies of the gene of the asthmatic group with those of the healthy control group. RESULTS: There was no significant difference in genotype and allele frequencies of CC16 gene between the asthmatic group and control group. There was no association between the genotype and allele frequencies of gene and the severity of asthma. CONCLUSION:CC16 gene may be not a susceptibility gene of asthmatic patients of Han population in southwest China.