OBJECTIVES: To study the epidemiological trends, clinical patterns, evolution and prognosis of HIV infection in women. DESIGN: Cohort study of 1816 HIV-infected patients. RESULTS: Up to 1 January 1991, 483 (26.6%) of the patients reported to the Groupe d'Epidemiologie Clinique du SIDA en Aquitaine surveillance system were women. The male-to-female ratio has decreased progressively (3.4:1 in 1985; 2.7:1 in 1990) over time. Fifty per cent of HIV-infected women are or have been intravenous drug users (IVDU). The proportion of heterosexually acquired HIV infection increased from 11.6 to 34.6% over the last 5 years; 46.9% of the women infected through heterosexual intercourse reported sexual contacts with male IVDU. Excluding Kaposi's sarcoma, no significant difference was observed between men and women in the overall distribution of AIDS-defining events. The observed trend of a slower progression to AIDS in women, compared with men, disappeared when controlling for prognostic variables. However, female sex significantly enhanced survival after AIDS diagnosis in multivariate analysis (relative risk, 2.7; 95% confidence interval, 1.1-6.2). CONCLUSION: Early diagnosis of HIV infection in female patients and prevention of HIV infection among women is now a priority for public health interventions, both in industrialized and in developing countries.
OBJECTIVES: To study the epidemiological trends, clinical patterns, evolution and prognosis of HIV infection in women. DESIGN: Cohort study of 1816 HIV-infectedpatients. RESULTS: Up to 1 January 1991, 483 (26.6%) of the patients reported to the Groupe d'Epidemiologie Clinique du SIDA en Aquitaine surveillance system were women. The male-to-female ratio has decreased progressively (3.4:1 in 1985; 2.7:1 in 1990) over time. Fifty per cent of HIV-infectedwomen are or have been intravenous drug users (IVDU). The proportion of heterosexually acquired HIV infection increased from 11.6 to 34.6% over the last 5 years; 46.9% of the women infected through heterosexual intercourse reported sexual contacts with male IVDU. Excluding Kaposi's sarcoma, no significant difference was observed between men and women in the overall distribution of AIDS-defining events. The observed trend of a slower progression to AIDS in women, compared with men, disappeared when controlling for prognostic variables. However, female sex significantly enhanced survival after AIDS diagnosis in multivariate analysis (relative risk, 2.7; 95% confidence interval, 1.1-6.2). CONCLUSION: Early diagnosis of HIV infection in female patients and prevention of HIV infection among women is now a priority for public health interventions, both in industrialized and in developing countries.
Authors: Ruxandra Burlacu; Anya Umlauf; Anca Luca; Sara Gianella; Roxana Radoi; Simona M Ruta; Thomas D Marcotte; Luminita Ene; Cristian L Achim Journal: AIDS Date: 2018-01-14 Impact factor: 4.177
Authors: Melinda E Wilson; Filomena O Dimayuga; Janelle L Reed; Thomas E Curry; Carol F Anderson; Avindra Nath; Annadora J Bruce-Keller Journal: Endocrine Date: 2006-04 Impact factor: 3.633
Authors: R Burlacu; A Umlauf; T D Marcotte; B Soontornniyomkij; C C Diaconu; A Bulacu-Talnariu; A Temereanca; S M Ruta; S Letendre; L Ene; C L Achim Journal: J Neurovirol Date: 2019-08-14 Impact factor: 2.643
Authors: Knut A Hestad; J Anitha Menon; Mary Silalukey-Ngoma; Donald R Franklin; Mwiya L Imasiku; Kalima Kalima; Robert K Heaton Journal: J Nerv Ment Dis Date: 2012-04 Impact factor: 2.254
Authors: Ashley M Behrman-Lay; Robert H Paul; Jodi Heaps-Woodruff; Laurie M Baker; Christina Usher; Beau M Ances Journal: J Neurovirol Date: 2015-08-26 Impact factor: 2.643